Application of Point-of-care Ultrasound in Rapid Assessment of Cardiac Arrest Patients

NCT05859516 | Unknown

• 1 other identifier: 2022003
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

To quickly assess the patient's cardiac function and structure through ultrasound

Conditions

Cardiac Arrest; Point-of-care Ultrasound; Cardiopulmonary Resuscitation

Keywords

Cardiac Arrest; Point-of-care Ultrasound; cardiopulmonary resuscitation quality

Outcome Measures

Primary Outcomes (1)

• The correlation between return of spontaneous circulation rate and peripheral blood flow through study completion, an average of 1 hour.

  For patients with cardiac arrest undergoing CPR, Peripheral arterial blood flow monitoring was completed by ultrasound, and compared with treturn of spontaneous circulation rate . Bilateral carotid blood flow velocity: 1. Peak systolic velocity, PSV, cm/s 2. End diastolic velocity, EDV,cm/s 3. Resistance index, RI 4. Pulsatility index, PI Bilateral femoral artery blood flow velocity 1\) Peak systolic velocity, PSV, cm/s 2) End diastolic velocity, EDV,cm/s 3) Resistance index, RI 4) Pulsatility index, P

  through study completion, an average of 1 hour.

Study Arms (1)

Experimental: Ultrasound

Diagnostic Test: Ultrasound

Interventions

Ultrasound DIAGNOSTIC_TEST

Every time checking pulse, evaluate the carotid artery compressibility and blood flow of peripheral arteries by ultrasound，compared with EtCO2.

Experimental: Ultrasound

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Emergency Department patients

You may qualify if:

• Voluntarily participate and sign a written informed consent;
• Male or female above 18;
• Patients who are sent to the emergency room of our hospital with symptoms of "cardiopulmonary resuscitation";

You may not qualify if:

• There is trauma in the ultrasound examination site and it is not suitable for ultrasound examination;
• Entering the emergency room without vital signs for more than 30 minutes;
• The appearance of corpse corpses;
• There is life-threatening and irreversible damage;
• Other investigators consider it inappropriate and the patient or family member refuses;

Sponsors & Collaborators

• Zhongnan Hospital: lead

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430000, China

RECRUITING

Related Publications (13)

• Pandor A, Fuller G, Essat M, Sabir L, Holt C, Buckley Woods H, Chatha H. Individual risk factors predictive of major trauma in pre-hospital injured older patients: a systematic review. Br Paramed J. 2022 Mar 1;6(4):26-40. doi: 10.29045/14784726.2022.03.6.4.26.

  PMID: 35340581 BACKGROUND

• Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. JAMA. 2021 Jan 26;325(4):382-390. doi: 10.1001/jama.2020.20317.

  PMID: 33496779 BACKGROUND

• Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.

  PMID: 26903338 BACKGROUND

• Reynolds JC, Nicholson T, O'Neil B, Drennan IR, Issa M, Welsford M; Advanced Life Support Task Force at the International Liaison Committee on Resuscitation ILCOR. Diagnostic test accuracy of point-of-care ultrasound during cardiopulmonary resuscitation to indicate the etiology of cardiac arrest: A systematic review. Resuscitation. 2022 Mar;172:54-63. doi: 10.1016/j.resuscitation.2022.01.006. Epub 2022 Jan 19.

  PMID: 35065210 BACKGROUND

• Montoya J, Stawicki SP, Evans DC, Bahner DP, Sparks S, Sharpe RP, Cipolla J. From FAST to E-FAST: an overview of the evolution of ultrasound-based traumatic injury assessment. Eur J Trauma Emerg Surg. 2016 Apr;42(2):119-26. doi: 10.1007/s00068-015-0512-1. Epub 2015 Mar 14.

  PMID: 26038031 BACKGROUND

• Keikha M, Salehi-Marzijarani M, Soldoozi Nejat R, Sheikh Motahar Vahedi H, Mirrezaie SM. Diagnostic Accuracy of Rapid Ultrasound in Shock (RUSH) Exam; A Systematic Review and Meta-analysis. Bull Emerg Trauma. 2018 Oct;6(4):271-278. doi: 10.29252/beat-060402.

  PMID: 30402514 BACKGROUND

• Dicker SA. Lung Ultrasound for Pulmonary Contusions. Vet Clin North Am Small Anim Pract. 2021 Nov;51(6):1141-1151. doi: 10.1016/j.cvsm.2021.07.001. Epub 2021 Sep 11.

  PMID: 34521570 BACKGROUND

• Lichtenstein D. Fluid administration limited by lung sonography: the place of lung ultrasound in assessment of acute circulatory failure (the FALLS-protocol). Expert Rev Respir Med. 2012 Apr;6(2):155-62. doi: 10.1586/ers.12.13.

  PMID: 22455488 BACKGROUND

• Kang SY, Jo IJ, Lee G, Park JE, Kim T, Lee SU, Hwang SY, Shin TG, Kim K, Shim JS, Yoon H. Point-of-care ultrasound compression of the carotid artery for pulse determination in cardiopulmonary resuscitation. Resuscitation. 2022 Oct;179:206-213. doi: 10.1016/j.resuscitation.2022.06.025. Epub 2022 Jul 2.

  PMID: 35792305 BACKGROUND

• Sheak KR, Wiebe DJ, Leary M, Babaeizadeh S, Yuen TC, Zive D, Owens PC, Edelson DP, Daya MR, Idris AH, Abella BS. Quantitative relationship between end-tidal carbon dioxide and CPR quality during both in-hospital and out-of-hospital cardiac arrest. Resuscitation. 2015 Apr;89:149-54. doi: 10.1016/j.resuscitation.2015.01.026. Epub 2015 Jan 30.

  PMID: 25643651 BACKGROUND

• Genbrugge C, Dens J, Meex I, Boer W, Eertmans W, Sabbe M, Jans F, De Deyne C. Regional Cerebral Oximetry During Cardiopulmonary Resuscitation: Useful or Useless? J Emerg Med. 2016 Jan;50(1):198-207. doi: 10.1016/j.jemermed.2015.03.043. Epub 2015 Sep 26.

  PMID: 26412107 BACKGROUND

• Reynolds JC, Issa MS, C Nicholson T, Drennan IR, Berg KM, O'Neil BJ, Welsford M; Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Prognostication with point-of-care echocardiography during cardiac arrest: A systematic review. Resuscitation. 2020 Jul;152:56-68. doi: 10.1016/j.resuscitation.2020.05.004. Epub 2020 May 11.

  PMID: 32437781 BACKGROUND

• Kedan I, Ciozda W, Palatinus JA, Palatinus HN, Kimchi A. Prognostic value of point-of-care ultrasound during cardiac arrest: a systematic review. Cardiovasc Ultrasound. 2020 Jan 13;18(1):1. doi: 10.1186/s12947-020-0185-8.

  PMID: 31931808 BACKGROUND

Biospecimen

Retention: NONE RETAINED

whole blood; serum; urine

MeSH Terms

Conditions

Heart Arrest

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Jian Xia, Dr.

  Wuhan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hao Zou, Dr.

CONTACT

86-27-67813337; zouhao@whu.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2023
• First Posted: May 16, 2023
• Study Start: February 1, 2023
• Primary Completion: January 31, 2024
• Study Completion: June 30, 2024
• Last Updated: May 16, 2023

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)