The Value of Ultrasound Elastography for Differentiating Benign and Malignant Superficial Soft Tissue Masses

NCT05692141 | Unknown

• 1 other identifier: elastography
• Study Type: observational
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

Ultrasonography has the advantages of being widely available, cost-effective, and allowing real-time dynamic examinations. Additionally, it is less time-consuming than magnetic resonance imaging (MRI) \[1,2\]. Recently developed ultrasound elastography techniques provide valuable information about intrinsic tissue properties by evaluating tissue elasticity, which may contribute to the diagnosis \[3,4\]. Ultrasound elastography can quantify and qualify tissue elasticity and add important information to the findings obtained by conventional ultrasonography \[3,5-7\]. Superficial soft tissue masses frequently occur and primarily manifest as benign lesions (including lipoma and hemangioma) that typically do not require treatment. Although malignant masses are rare, prompt surgical resections are required following the confirmation of a diagnosis (8). Therefore, differentiating between benign and malignant masses is important to prevent delays in the treatment of the malignant masses and avoid unnecessary surgical treatments for the benign masses (9). As the most effective method, pathological diagnosis is typically obtained from a needle biopsy. However, it is an invasive maneuver that is uncomfortable for patients and impractical for all types of soft tissue masses (10). Ultrasound is the primary examination method for superficial soft tissue masses to confirm their size, location, and the association between the masses and the surrounding structures. Through observations of the borders of the tissue masses, internal echo characteristics, and internal blood flow signals, ultrasounds may provide a preliminary diagnosis that is inaccurate (11). Stiffness of the tissue structures may be accessed using ultrasound elastography (UE) (12), which is an effective tool for differentiating malignant and benign masses (13). The stiffness of a malignant tumor is typically higher compared with a benign tumor. Previously, the differential diagnosis was primarily based on palpations by the physicians, which was indirect and could be limited in patients with obesity, mass sizes and depths, and physicians' experiences.

Conditions

Ultrasound Therapy; Complications

Outcome Measures

Primary Outcomes (1)

• to investigate the value of ultrasound Elastography for differentiating benign and malignant superficial soft tissue masses .

  to investigate the value of ultrasound Elastography for differentiating benign and malignant superficial soft tissue masses .

  baseline

Interventions

ultrasound DEVICE

For each lesion, ultrasound Elastography would be performed using a Linear probe ;

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will analyze patients who receive care at our institution patients with soft tissue masses. We retrospectively investigate patients' medical records, ultrasonographic exams, and histopathology reports

You may qualify if:

• patients with superficial masses

You may not qualify if:

• inflammatory lesions

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Yeoh HJ, Kim TY, Ryu JA. The feasibility of shear wave elastography for diagnosing superficial benign soft tissue masses. Ultrasonography. 2019 Jan;38(1):37-43. doi: 10.14366/usg.17059. Epub 2018 Jan 19.

  PMID: 29580047 BACKGROUND

MeSH Terms

Interventions

Ultrasonography

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Aliaa Sayed, Resident

CONTACT

01094367328; hadeersayed2211@gmail.com

Gehan Sayed, prof

CONTACT

01061622667; gehanseifeldein@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assuit

Study Record Dates

• First Submitted: January 11, 2023
• First Posted: January 20, 2023
• Study Start: February 1, 2023
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2024
• Last Updated: January 20, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share