Autobiographical Specificity

NCT05642351 | Recruiting

• 1 other identifier: RC22_0626
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.

Conditions

Memory; Alzheimer Disease; Frontotemporal Dementia

Keywords

Autobiographical memory; Alzheimer's disease; with behavioral variant of frontotemporal dementia

Outcome Measures

Primary Outcomes (1)

• Autobiographical specificity

  We will apply the method by Raes et al. (2007) to assess whether each retrieved event refers to a: specific event, categorical event, extended event, or semantic event

  40 minutes

Study Arms (2)

Alzheimer's Disease

recruited according to criteria by National Institute on Aging (McKhann et al., 2011).

Other: Autobiographical reminder

Behavioral variant of frontotemporal dementia

recruited following criteria by Rascovsky et al. (2011)

Other: Autobiographical reminder

Interventions

Autobiographical reminder OTHER

The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: * 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") * 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") * 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") * 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") * 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") * 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Alzheimer's Disease; Behavioral variant of frontotemporal dementia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All participants will be recruited through the active file of memory consultations of the "memory resource and research center" (CMRR) of the Nantes University Hospital.

You may qualify if:

• Alzheimer' disease or avioral variant of frontotemporal dementia
• No opposition from the patient to be included in the study
• For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)

You may not qualify if:

• Other psychiatric/neurological disorders
• Minor patients
• Adults under guardianship or protection.

Sponsors & Collaborators

• Nantes University Hospital: lead

Study Sites (1)

EL HAJ Mohamad

Nantes, France

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease; Frontotemporal Dementia

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Frontotemporal Lobar Degeneration; TDP-43 Proteinopathies; Proteostasis Deficiencies; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Mohamad EL HAJ

CONTACT

02 40 68 66 60; mohamad.elhaj@univ-nantes.fr

Claire Boutoleau Bretonnière

CONTACT

02 40 16 57 05; claire.boutoleaubretonniere@chu-nantes.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2022
• First Posted: December 8, 2022
• Study Start: February 3, 2023
• Primary Completion: December 3, 2025
• Study Completion: December 3, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)