Validation of a Remediation Method for Memory Disorders Using Motor and Emotional Encoding in Patients With Alzheimer's Disease

NCT06105047 | Completed

• 2 other identifiers: 23CH154ANSM
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 3

Brief Summary

Memories are more robust when they are multitraced. This means that the more a piece of information is mediated by different sensory inputs, the more resistant it is to being forgotten. Many works in the field of embodied cognition show that new learnings are better recalled over the long term when they are learned during body mobilization. Other works show that musical stimulation could be a good way of eliciting physiological and emotional states more favorable to the memorization of new contents. However, to date, no studies have examined the positive effects of these two tools combined in Alzheimer's disease. The investigators suggest that it is possible to optimize memory in Alzheimer's disease by referring to their motor and emotional resources. The hypothesis is that information will be better recalled with multimodal enriched learning.

Conditions

Alzheimer Disease

Keywords

Alzheimer; Action memory; Musical memory

Outcome Measures

Primary Outcomes (1)

• "Discrimination score"

  Comparison of the recognition score obtained in each of the experimental conditions to the recognition score obtained in the control condition The score = the Number of correct answer (0 to 15, the higher score means better outcome)

  Weeks: 2

Secondary Outcomes (1)

• "Geneva Music-Induced Affect Checklist" scale

  Weeks: 2

Study Arms (1)

Patients with Alzheimer disease

EXPERIMENTAL

Patients will perform experimental task in four conditions : control, mime, emotion, dual

Behavioral: Cognitive tests

Interventions

Cognitive tests BEHAVIORAL

. Patients will perform experimental task in four conditions : control, mime, emotion, dual In a control condition : they will be asked to read the sentence aloud; in a motor-only condition, they will also be asked to mime the sentence; in an emotional-only condition, they will be asked to read the sentence while listening to music; in a dual condition, they will be asked to both mime and listen to music. Immediately after each condition, they will realize a recognition task * quiz : Geneva Music Induced Checklist, GMIAC, Coutinho \& Scherer, 2017

Patients with Alzheimer disease

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of Alzheimer's disease by one of the consulting physicians, neurologist and/or geriatrician of whom the patient has been informed.
• Early stage (MMSE ≥ 22)
• Affiliation with a social security scheme
• Age equal to or greater than 60
• French mother tongue
• Agreement to participate / signature of consent form

You may not qualify if:

• Uncorrected perceptual disorders
• Other neurological or psychiatric history
• Inability to communicate
• Delusional or psychotic state
• Person unable to give informed consent
• Refusal to participate
• Participation in a study on a drug/medical device/care technique likely to affect cognitive functions

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (3)

CHU Grenoble

Grenoble, France

Location

CHU de Saint-Etienne

Saint-Etienne, 42055, France

Location

HCL

Villeurbanne, France

Location

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Céline BORG, MD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 23, 2023
• First Posted: October 27, 2023
• Study Start: January 22, 2024
• Primary Completion: May 9, 2025
• Study Completion: May 16, 2025
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (3)