The Reliability and Validity of the L-test in Patients With Multiple Sclerosis

NCT05641714 | Completed

• 1 other identifier: 1-MS-L-Test-reliability
• Study Type: observational
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Walking safely inside or outside is an important function in patients with Multiple Sclerosis (PwMS) that affects their daily life activity and participation. Loss of functional mobility is the major component of walking disorders in PwMS. Therefore, it is important to evaluate functional mobility. Many functional mobility tests have been used for PwMS; however, these tests generally focus on walking speed and endurance. On the other hand, the L test, a variation of the timed up and go test (TUG), is a functional mobility measurement tool that extends the total walking distance to 20 meters and also requires the patients to turn both clockwise and counterclockwise. Although L the test is an easy-to-use, short-term test method that evaluates higher-level components of functional mobility such as turns and transfers, to our knowledge, no study has systematically examined the reliability and validity of the L test in PwMS yet. In addition, the cut-off times that best discriminate PwMS from healthy people and fallers with non-fallers with Multiple Sclerosis (MS) have not been reported. Therefore, this study planned to investigate the reliability, validity, and discrimination of the L test in PwMS.

Conditions

Multiple Sclerosis

Keywords

L test; multiple sclerosis; functional mobility; reliability; validity

Outcome Measures

Primary Outcomes (2)

• L test

  The L test evaluates functional mobility. Higher durations indicate worse functional mobility performance.

  baseline

• L test-second assessment

  The L test evaluates functional mobility. Higher durations indicate worse functional mobility performance.

  the second assessment will be conducted after the seven days

Secondary Outcomes (4)

• Timed Up and Go test

  Baseline

• 10 meter walk test

  Baseline

• 6 minute walk test

  Baseline

• the timed 360° turn test

  Baseline

Study Arms (2)

multiple sclerosis

Patients with Multiple Sclerosis

Other: L test; Other: Timed Up and Go test; Other: 10 meter walk test; Other: Six Minute Walk Test; Other: The timed 360° turn test

healthy controls

healthy controls

Other: L test

Interventions

L test OTHER

The test includes standing up from a chair, walking in a straight line for 3 m, turning to the right, walking in a straight line for 7 m, turning around, walking back 7 m along the same line, turning to the left, walk 3 m in a straight line to the chair, and then sit down.

healthy controls; multiple sclerosis

Timed Up and Go test OTHER

The test requires the individual to stand up from an armed chair, walk 3m, turn around, walk back to the armed chair, and sit down again.

multiple sclerosis

10 meter walk test OTHER

In the test, the clinician measures the time taken to walk a distance of 10 m from a standing position. Participants are asked to walk along a 14 m long walkway.

multiple sclerosis

Six Minute Walk Test OTHER

This test measures the distance (in m) that an individual is able to walk at a comfortable speed for 6 minutes. Starting from a standing position, participants walk continuously around two pylons placed 30 m apart for 6 minutes. The distance is recorded end of the test.

multiple sclerosis

The timed 360° turn test OTHER

Each participant turns around in place in a standing position for both sides.

multiple sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with Multiple Sclerosis who apply to Gazi University, Department of Physiotherapy and Rehabilitation will be invited to this study.

You may qualify if:

• Age at least 18 years,
• Neurologist-diagnosed Multiple Sclerosis,
• Expanded Disability Status Scale (EDSS) score between 0-5,
• No MS exacerbation within the last 3 months,
• Use of stable medication in the last 3 months.

You may not qualify if:

• Having any vision, hearing, or perception problems that may affect the research results,
• Having an orthopedic problem that will prevent walking and standing
• Having a cardiovascular, pulmonary, or hormonal disorder

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University

Ankara, Turkey (Türkiye)

Location

Related Publications (3)

• Kim JS, Chu DY, Jeon HS. Reliability and validity of the L test in participants with chronic stroke. Physiotherapy. 2015 Jun;101(2):161-5. doi: 10.1016/j.physio.2014.09.003. Epub 2014 Oct 28.

  PMID: 25555897 BACKGROUND

• Deathe AB, Miller WC. The L test of functional mobility: measurement properties of a modified version of the timed "up & go" test designed for people with lower-limb amputations. Phys Ther. 2005 Jul;85(7):626-35.

  PMID: 15982169 BACKGROUND

• Eldemir K, Eldemir S, Ozkul C, Irkec C, Guclu-Gunduz A. Reliability and validity of the L test in people with multiple sclerosis. Physiotherapy. 2025 Mar;126:101429. doi: 10.1016/j.physio.2024.101429. Epub 2024 Sep 24.

  PMID: 39541755 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: November 24, 2022
• First Posted: December 8, 2022
• Study Start: December 15, 2022
• Primary Completion: January 16, 2023
• Study Completion: January 16, 2023
• Last Updated: February 23, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)