Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin
1 other identifier
interventional
54
1 country
1
Brief Summary
The present prospective clinical study will be undertaken for assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization\& intrusion of anterior teeth in deep bite cases
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1
Started Jan 2023
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 9, 2022
CompletedFirst Posted
Study publicly available on registry
November 15, 2022
CompletedStudy Start
First participant enrolled
January 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2023
CompletedNovember 15, 2022
November 1, 2022
3 months
November 9, 2022
November 9, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
effect of injectable platelet rich fibrin on different tooth movements
rate of tooth movement
post interventional at 4 months
Study Arms (6)
Group I
EXPERIMENTALIntervention side: application of i-PRF with distalization of maxillary first molar that will be performed on intervention sides according to a standardized protocol.
Group II
NO INTERVENTIONControl side: distalization of maxillary first molar that will be performed without any intervention
Group A
EXPERIMENTALlevelling and alignment assisted with Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.
Group B
NO INTERVENTIONleveling and alignment will be commenced without Injection of Injectable platelet-rich fibrin (i-PRF)
Group a
EXPERIMENTALWill includes 9 patients who will receive intrusive arch after leveling and alignment assisted Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.
Group b
NO INTERVENTIONWill includes 9 patients who will receive intrusive utility arches after leveling and alignment without Injection of Injectable platelet-rich fibrin (i-PRF)
Interventions
Eligibility Criteria
You may qualify if:
- All permanent teeth present, 3rd molars are excluded. Good oral and general health. No systemic disease/medication that could interfere with orthodontic tooth movement. No previous orthodontic treatment.
You may not qualify if:
- Poor oral hygiene or periodontally compromised patient. Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
AlAzhar university
Cairo, Egypt
Related Publications (2)
Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial. J Orofac Orthop. 2021 Jul;82(4):268-277. doi: 10.1007/s00056-020-00275-x. Epub 2021 Jan 22.
PMID: 33481053BACKGROUNDErdur EA, Karakasli K, Oncu E, Ozturk B, Hakki S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021 May 1;91(3):285-292. doi: 10.2319/060320-508.1.
PMID: 33459765BACKGROUND
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
November 9, 2022
First Posted
November 15, 2022
Study Start
January 1, 2023
Primary Completion
April 1, 2023
Study Completion
April 1, 2023
Last Updated
November 15, 2022
Record last verified: 2022-11
Data Sharing
- IPD Sharing
- Will not share