NCT05615831

Brief Summary

The primary objective is to investigate whether six weeks of resistance training, in combination with blood flow restriction, produces a different adaptation in fat-free mass between males and females that are not physically active. The secondary objective is to compare changes in physical function, physical performance, and blood biomarkers between males and females following resistance training and blood flow restriction.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
72

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2022

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 20, 2022

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 14, 2022

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 22, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 22, 2023

Completed
Last Updated

December 13, 2023

Status Verified

December 1, 2023

Enrollment Period

1.6 years

First QC Date

September 20, 2022

Last Update Submit

December 12, 2023

Conditions

Physical Activity

Keywords

Blood flow restrictionSex comparisonsResistance trainingSex DifferencesAgingYoung healthyStrength Training

Outcome Measures

Primary Outcomes (1)

  • Muscle hypertrophy

    Change in fat-free mass

    Baseline and 6 weeks

Secondary Outcomes (5)

  • Strength

    Baseline and 6 weeks

  • Muscle Power

    Baseline and 6 weeks

  • Muscle Endurance

    Baseline and 6 weeks

  • Changes in physical function

    Baseline and 6 weeks

  • Changes in blood biomarkers

    Baseline and 6 weeks post-intervention and pre and post an acute bout of resistance training at baseline and and after 6 weeks

Study Arms (2)

Young adult (19-30 years)

EXPERIMENTAL

Individuals aged 19-30 who are not physically active will participate in resistance training combined with blood flow restriction.

Behavioral: Resistance Training with Blood flow restriction

Older adults adult (aged 65 years and older)

EXPERIMENTAL

Individuals aged 65 years and older who are not physically active will participate in resistance training combined with blood flow restriction.

Behavioral: Resistance Training with Blood flow restriction

Interventions

Resistance Training with Blood flow restrictionBEHAVIORAL

Participants will perform six weeks of blood flow restriction (60% occlusion) combined with resistance training at 30% of 1RM. The intervention comprises five exercises: incline chest press, seated row, leg press, knee extension, and knee flexion. The protocol is as follows: 30 repetitions followed by three sets of 15 repetitions for a total of four sets and 75 repetitions per exercise. There will be a one-minute recovery between sets where the cuffs remain inflated and a four-minute recovery between exercises where the cuffs will be deflated.

Older adults adult (aged 65 years and older)Young adult (19-30 years)

Eligibility Criteria

Age19 Years - 100 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between the ages of 19 and 100 years
  • Sedentary (not meeting physical activity guidelines), but otherwise healthy

You may not qualify if:

  • Aged outside the threshold
  • Uncontrolled hypertension
  • Presence of cardiovascular disease
  • Either surgery, bone fracture, or skin graft within the previous three months
  • Uncontrolled diabetes mellitus
  • Pregnancy
  • Individuals taking medications known to increase risk of blood clotting

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of New Brunswick - Kinesiology

Fredericton, New Brunswick, E3B 5A3, Canada

Location

Related Publications (1)

  • Arnason JK, Thomson AM, Peskett LE, Nancekievill DA, Bouchard DR, Senechal M. Age-Related Differences in Adaptation of Lean Body Mass, Muscle Strength, and Performance Following 6 Weeks of Blood Flow Restriction Training in Young and Older Adults. J Frailty Sarcopenia Falls. 2025 Mar 1;10(1):37-47. doi: 10.22540/JFSF-10-037. eCollection 2025 Mar.

    PMID: 40035085DERIVED

MeSH Terms

Conditions

Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Martin Senechal, PhD

    University of New Brunswick

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, Martin Senechal, Ph.D.

Study Record Dates

First Submitted

September 20, 2022

First Posted

November 14, 2022

Study Start

May 1, 2022

Primary Completion

November 22, 2023

Study Completion

November 22, 2023

Last Updated

December 13, 2023

Record last verified: 2023-12

Locations

CA(1)