NCT03499977

Brief Summary

This study will examine whether 10-minute bouts of cycling at various intensities will impact executive functioning (i.e., cognitive ability) as assessed by the antisaccade (AS) task through a total of five visits. An antisaccade is a rapid eye movement away from a visual target. The ability to suppress making an eye movement towards a visual target gauges inhibitory control (i.e., a domain of executive functioning). In the initial visit, participants' exercise capacity will be assessed through a maximal effort cycling test. Intensities for the cycling bouts (i.e., high, moderate, low) in subsequent sessions will be based upon this maximal effort cycling test. In visits 2 through 5, participants will complete an AS task, followed by a 10-minute bout of cycling, and then complete the AS task again. The order of cycling intensities will be randomized between participants. Differences in the AS task (i.e., reaction time and accuracy) will be compared between and within cycling conditions.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 9, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 17, 2018

Completed
3 months until next milestone

Study Start

First participant enrolled

July 1, 2018

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2018

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2019

Completed
Last Updated

May 6, 2024

Status Verified

May 1, 2024

Enrollment Period

6 months

First QC Date

April 9, 2018

Last Update Submit

May 2, 2024

Conditions

Physical Activity

Keywords

Physical ActivityExecutive functionAnti-saccade

Outcome Measures

Primary Outcomes (2)

  • Reaction Time

    Time in milliseconds to target

    30 minutes

  • Accuracy

    Directional errors

    30 minutes

Other Outcomes (1)

  • Heart Rate

    10 minutes

Study Arms (4)

Sitting

EXPERIMENTAL

The participant will be asked to sit for 10 min (not increasing their heart rate) then do the anti-saccade task

Behavioral: Sitting

Low-Intensity Cycling

EXPERIMENTAL

Participant will be asked to cycle for 10 min (\<40% VO2R) and then perform the anti-saccade task

Behavioral: Light-Intensity Cycling

Moderate-Intensity Cycling

EXPERIMENTAL

The participant will be asked to do 10 min of cycling (40-59% VO2R) followed but the anti-saccade task

Behavioral: Moderate-Intensity Cycling

High-Intensity Cycling

EXPERIMENTAL

The participant will be asked to do 10 min of cycling (60%-84% VO2R) followed but the anti-saccade task

Behavioral: High-Intensity Cycling

Interventions

SittingBEHAVIORAL

10 min bouts

Sitting
Light-Intensity CyclingBEHAVIORAL

10min bout

Low-Intensity Cycling
Moderate-Intensity CyclingBEHAVIORAL

10 min bout

Moderate-Intensity Cycling
High-Intensity CyclingBEHAVIORAL

10 min bout

High-Intensity Cycling

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Able to read, write and understand English
  • Full time student enrolled at Western University
  • Able to perform a ten-minute exercise task at a light intensity without health implications
  • Have email or phone number for contacting purposes

You may not qualify if:

  • Do not have a medical condition that prevents you from exercise (e.g. heart attack in the past year, heart disease, irregular heartbeat, etc.)
  • Do not have history of eye injury or neurological impairment
  • Do not have an orthopaedic limitation
  • Are not pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Western University

London, Ontario, N6A3K7, Canada

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Sitting Position

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

PostureMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Harry Prapavessis, Ph.D

    Western University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 9, 2018

First Posted

April 17, 2018

Study Start

July 1, 2018

Primary Completion

December 31, 2018

Study Completion

July 31, 2019

Last Updated

May 6, 2024

Record last verified: 2024-05

Data Sharing

IPD Sharing
Will not share

Locations

CA(1)