NCT05512884

Brief Summary

The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 17, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 23, 2022

Completed
5 months until next milestone

Study Start

First participant enrolled

January 15, 2023

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2023

Completed
Last Updated

January 19, 2023

Status Verified

January 1, 2023

Enrollment Period

8 months

First QC Date

August 17, 2022

Last Update Submit

January 16, 2023

Conditions

Aphasia

Keywords

AnomiaSpeech DisordersLanguage DisordersCommunication Disorders

Outcome Measures

Primary Outcomes (3)

  • Speeded anomia therapy effect in reaction time

    Change in reaction time in single-item picture naming

    Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)

  • Speeded anomia therapy effect in accuracy

    Change in accuracy in single-item picture naming

    Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)

  • Generalisation to connected speech

    Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).

    Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)

Secondary Outcomes (1)

  • Generalisation to story-telling connected speech

    Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)

Study Arms (2)

Speeded anomia therapy

EXPERIMENTAL

21h of anomia therapy

Behavioral: Speeded anomia therapy

Standard care

NO INTERVENTION

Participants' typical daily routine

Interventions

Speeded anomia therapyBEHAVIORAL

The speeded anomia therapy was introduced as RISP (Repeated, Increasingly Speeded Production) by Conroy et al. (2018). Participants are asked to name the picture presented to them before an auditory stimulus ('beep' sound) at the end of item presentation. In each session the allotted response time is gradually reduced. After an incorrect response, participants are asked to repeat the word three times.

Speeded anomia therapy

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Native English speakers
  • Age 18 years or above
  • Stroke (any type) greater than 12 months post onset
  • No history of neurological disorders / psychiatric disorders
  • Normal or corrected-to-normal hearing \& vision
  • Able to give informed consent
  • Currently not receiving Speech \& Language therapy
  • Minimal repetition skills (\>40% on an immediate word repetition test)
  • Evidence of naming difficulties (\<90% in Boston Naming Test - Goodglass et al., 1983)

You may not qualify if:

  • Non-native English speakers
  • Less than 18 years old
  • Stroke less than 12 months post onset
  • History of neurological disorders / psychiatric disorders
  • Uncorrected hearing \& vision
  • Unable to give informed consent
  • Currently receiving Speech \& Language therapy
  • Insufficient repetition skills (\<40% on an immediate word repetition test)
  • Good naming performance (\>90% in Boston Naming Test - Goodglass et al., 1983)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

MRC Cognition & Brain Sciences Unit

Cambridge, CB2 7EF, United Kingdom

RECRUITING

Related Publications (1)

  • Conroy P, Sotiropoulou Drosopoulou C, Humphreys GF, Halai AD, Lambon Ralph MA. Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. Brain. 2018 Jun 1;141(6):1815-1827. doi: 10.1093/brain/awy087.

    PMID: 29672757BACKGROUND

MeSH Terms

Conditions

AphasiaAnomiaSpeech DisordersLanguage DisordersCommunication Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurodevelopmental DisordersMental Disorders

Study Officials

  • Matthew Lambon Ralph, DPhil

    MRC Cognition and Brain Sciences Unit, University of Cambridge

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Eleni Zevgolatakou, MSc

CONTACT

+447724386296Elena.Zevgolatakou@mrc-cbu.cam.ac.uk

Ajay Halai, PhD

CONTACT

+447508764348Ajay.Halai@mrc-cbu.cam.ac.uk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

August 17, 2022

First Posted

August 23, 2022

Study Start

January 15, 2023

Primary Completion

September 1, 2023

Study Completion

September 1, 2023

Last Updated

January 19, 2023

Record last verified: 2023-01

Locations

GB(1)