NCT07347327

Brief Summary

This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:

  1. 1.Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke?
  2. 2.Can it improve the integration of auditory information and speech motor control during communication?
  3. 3.Receive one extra 20-minute session of either real or sham tACS each day for 10 days
  4. 4.Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
28

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2023

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 26, 2025

Completed
3 days until next milestone

Study Completion

Last participant's last visit for all outcomes

December 29, 2025

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

January 9, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

January 16, 2026

Completed
Last Updated

January 22, 2026

Status Verified

January 1, 2026

Enrollment Period

3 years

First QC Date

January 9, 2026

Last Update Submit

January 20, 2026

Conditions

Aphasia

Outcome Measures

Primary Outcomes (1)

  • Western Aphasia Battery (WAB) score

    Western Aphasia Battery (WAB) score：0-100，higher score means better language function

    Baseline and 10-days

Study Arms (2)

real group

EXPERIMENTAL

dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

Behavioral: speech trainingOther: real tACS

sham group

SHAM COMPARATOR

sham tACS except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

Behavioral: speech trainingOther: sham tACS

Interventions

speech trainingBEHAVIORAL

speech training(especially repetition training) synchronized with tACS stimulation

real groupsham group
real tACSOTHER

dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

real group
sham tACSOTHER

except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

sham group

Eligibility Criteria

Age30 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
  • Age ranging from 30 to 80 years old;
  • Native language is Mandarin or Cantonese;
  • Right-handed;
  • Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
  • Able to cooperate in completing the speech repetition test;
  • Normal hearing.

You may not qualify if:

  • Currently receiving non-invasive brain stimulation treatment;
  • Lesions involving the Broca or STG brain regions;
  • History of epilepsy, mental illness,or other neurological or mental disorders;
  • Any contraindications for transcranial electrical stimulation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Location

MeSH Terms

Conditions

Aphasia

Condition Hierarchy (Ancestors)

Speech DisordersLanguage DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 9, 2026

First Posted

January 16, 2026

Study Start

January 1, 2023

Primary Completion

December 26, 2025

Study Completion

December 29, 2025

Last Updated

January 22, 2026

Record last verified: 2026-01

Locations

CN(1)