Expanded Access [11C] Methionine PET Imaging

NCT05511714 | Unknown

• 1 other identifier: EXAMPT
• Study Type: expanded_access
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The participants are being asked to get this PET scan because the participants have or may have cancer in the central nervous system (head, neck, or spine), and the investigator and the patient's physician thinks that this scan may provide useful information for the participant's treatment. Primary Objective To provide expanded access to L-\[11C\]methionine as a positron-emitting tracer in children and young adults for the positron emission tomography (PET) imaging of neoplasms of the central nervous system (CNS) and head and neck to guide therapeutic management of disease.

Conditions

Head and Neck Neoplasms; Central Nervous System Tumor

Interventions

L-(11C) methionine DRUG

Injected intravenously with 20 mCi/1.7 sq m body surface area of L-\[methyl-11C\]methionine (maximum prescribed dose: 20 mCi).

Also known as: methionine C 11

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All participants under the care of a SJCRH physician with known or suspected neoplastic disease of the CNS or head and neck are eligible for participation.
• No limit on age.
• Patients of all genders and all ethnic groups under the care of a SJCRH physician.
• Female participants of child-bearing age must not be lactating due to theoretical potential harm to the infant from exposure to radiation.
• Informed consent signed by participant, parent, or guardian according to the guidelines of the Institutional Review Board.

You may not qualify if:

• More than six L-\[11C\]methionine PET scans within the previous 12 months.
• Inability or willingness of patient, parent, or guardian to consent.

Sponsors & Collaborators

• St. Jude Children's Research Hospital: lead

Study Sites (1)

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

AVAILABLE

Related Links

• St. Jude Children's Research Hospital
• Clinical Trials Open at St. Jude

MeSH Terms

Conditions

Central Nervous System Neoplasms; Head and Neck Neoplasms

Interventions

Methionine; carbon-11 methionine

Condition Hierarchy (Ancestors)

Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Amino Acids, Sulfur; Sulfur Compounds; Organic Chemicals; Amino Acids, Essential; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Neutral

Study Officials

• Barry L. Shulkin, MD, MBA

  St. Jude Children's Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Barry L. Shulkin, MD, MBA

CONTACT

888-226-4343; referralinfo@stjude.org

Study Design

• Study Type: expanded access
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 19, 2022
• First Posted: August 23, 2022
• Last Updated: April 24, 2026

Record last verified: 2026-04

Locations

US (1)