Study Stopped
Administratively Terminated by PI
Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer
Evaluation of Cone Beam Kilovoltage Imaging During Radiation Therapy for Tumors of the Head and Neck
3 other identifiers
interventional
30
1 country
1
Brief Summary
To evaluate the use of cone beam computed tomography in treating head and neck to hopefully reduce side effects
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_2
Started Mar 2007
Typical duration for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 27, 2006
CompletedFirst Posted
Study publicly available on registry
July 28, 2006
CompletedStudy Start
First participant enrolled
March 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2010
CompletedResults Posted
Study results publicly available
August 21, 2014
CompletedMay 4, 2025
May 1, 2025
11 months
July 27, 2006
June 12, 2014
May 1, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Average Interfraction Shift of Patients Undergoing Radiotherapy
Determine the magnitude of the systematic error of patient positioning as determined by cone beam CT (CBCT) and the desired placement based on the treatment planning CT scan. Every day, prior to radiation treatment, a CBCT will be performed. The CBCT images will be compared to the radiation therapy planning CT image just taken.
Daily prior to radiation
Average Residual Error Motion of Patients Undergoing Radiotherapy
To determine the magnitude of random variance (random error) in radiotherapy treatment of head and neck neoplasms
Daily after each radiotherapy treatment
Study Arms (1)
Cone Beam CT
EXPERIMENTALInterventions
The margin around the area to be treated with radiation is decreased due the image guidance of the cone beam CT
Eligibility Criteria
You may qualify if:
- any patient receiving radiation therapy for a head and neck tumor assigned to the new Elekta Synergy Linare Accelerator
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
Related Publications (1)
Den RB, Doemer A, Kubicek G, Bednarz G, Galvin JM, Keane WM, Xiao Y, Machtay M. Daily image guidance with cone-beam computed tomography for head-and-neck cancer intensity-modulated radiotherapy: a prospective study. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1353-9. doi: 10.1016/j.ijrobp.2009.03.059. Epub 2009 Jun 18.
PMID: 19540071RESULT
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Pramila Rani Anne, MD
- Organization
- Thomas Jefferson University
Study Officials
- PRINCIPAL INVESTIGATOR
Pramila Rani Anne, MD
Thomas Jefferson University
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 27, 2006
First Posted
July 28, 2006
Study Start
March 1, 2007
Primary Completion
February 1, 2008
Study Completion
September 1, 2010
Last Updated
May 4, 2025
Results First Posted
August 21, 2014
Record last verified: 2025-05