Assessment of Severity of Liver Disease Before Surgery

NCT05503836 | Unknown

• 1 other identifier: surgery in cirrhotic patients
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

• Determine the ability of Child Pugh, MELD, and ALBI scores to predict mortality and morbidity in cirrhotic patients undergoing abdominal surgeries.
• Evaluate the prognostic efficacy of ALBI score versus CTP and MELD scores to predict mortality and morbidity in cirrhotic patients undergoing abdominal surgeries

Conditions

Cirrhosis, Liver

Outcome Measures

Primary Outcomes (1)

• frequency of deaths and number of cases with hepatic decompensation and compliication

  As we will follow up the patient for 30 days after surgery

  Between August 2022 and August 2024

Interventions

abdominal surgeries PROCEDURE

abdominal surgeries

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All confirmed cases of cirrhosis aged ≥ 18 years of either sex, admitted to the Assiut university hospitals for abdominal surgeries (elective or emergency) .

You may qualify if:

• o All confirmed cases of cirrhosis aged ≥ 18 years of either sex, admitted to the Assiut university hospitals for abdominal surgeries (elective or emergency) were enrolled in the study.
• Cirrhosis is confirmed by the following diagnostic criteria :
• Clinical history and examination with special stress on symptoms and signs of chronic liver disease with or without evidence of hepatic decompensation e.g. the presence of ascites and with or without evidence of complications e.g. jaundice, bleeding varices, ascites, and lower limb edema.
• Laboratory findings in the form of raised bilirubin, impaired coagulation profile, and/or low serum albumin.
• Abdominal ultrasonography revealing liver cirrhosis (coarse echo pattern, attenuated hepatic veins, irregular outlines, hypertrophy of caudate lobe and/or shrunken liver, and presence of splenomegaly, ascites )

You may not qualify if:

• o Cirrhotic patients undergoing extra abdominal surgeries.
• Patients admitted for liver transplantation.
• Patients less than 18 years of age.
• Patients refused to participate.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Naqvi IH, Talib A, Mahmood K, Abidi R, Rizvi SNZ. The ability of the new ALBI scoring in predicting mortality, complications and prognostic comparison among cirrhotics. Prz Gastroenterol. 2019;14(4):250-257. doi: 10.5114/pg.2019.83872. Epub 2019 Mar 25.

  PMID: 31988671 BACKGROUND

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• .Mohamed Omar, Professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Tasneem Khaled, Ass. lecturer

CONTACT

01098292141; tasneemkhaled23@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: August 6, 2022
• First Posted: August 17, 2022
• Study Start: August 15, 2022
• Primary Completion: August 30, 2024
• Study Completion: September 1, 2024
• Last Updated: August 17, 2022

Record last verified: 2022-08