Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in Liver Cirrhosis
Fractional Excretion of Urea: an Excellent Simple Tool for the Differential Diagnosis of Acute Kidney Injury in Liver Cirrhosis
1 other identifier
observational
100
0 countries
N/A
Brief Summary
The aim of this study is to evaluate the diagnostic performance of FEUrea for the differential diagnosis of AKI in patients with cirrhosis and ascites Specifically, the ability of FEUrea to distinguish between ATN versus Pre renal azotemia and HRS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2021
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 15, 2018
CompletedFirst Posted
Study publicly available on registry
September 18, 2018
CompletedStudy Start
First participant enrolled
May 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
January 31, 2022
CompletedFebruary 24, 2021
February 1, 2021
8 months
September 15, 2018
February 22, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
comparison of FEUrea in different types of AKI in liver cirrhosis
measurement of FEUrea in different types of AKI in decompansated liver cirrhosis to identify its cause
baseline
Study Arms (1)
FEUrea in decompensated liver cirrhosis
FEUrea for the differential diagnosis of AKI in patients with cirrhosis and ascites Specifically, the ability of FEUrea to distinguish between ATN versus Pre renal azotemia and HRS
Interventions
Eligibility Criteria
compensated and decompensated rrhotic patients
You may qualify if:
- Liver cirrhosis of any etiology diagnosed by clinical parameters involving laboratory tests, endoscopic or radiologic evidence of cirrhosis,
- History of decompensation (hepatic encephalopathy, ascites, variceal bleeding, jaundice)
- Age greater than 18 years
- Presence of moderate or severe ascites
You may not qualify if:
- Prior liver or kidney transplant,
- Advanced chronic kidney disease G4(GFR category grade 4) according to KDIGO guidelines.
- Patients on acute or chronic renal replacement therapy,
- Ambiguous diagnosis of AKI and phenotype of AKI,
- Patients with hepatocellular carcinoma.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (3)
Piano S, Brocca A, Angeli P. Renal Function in Cirrhosis: A Critical Review of Available Tools. Semin Liver Dis. 2018 Aug;38(3):230-241. doi: 10.1055/s-0038-1661372. Epub 2018 Jul 24.
PMID: 30041275BACKGROUNDDurand F, Olson JC, Nadim MK. Renal dysfunction and cirrhosis. Curr Opin Crit Care. 2017 Dec;23(6):457-462. doi: 10.1097/MCC.0000000000000457.
PMID: 29023314BACKGROUNDBucsics T, Krones E. Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome. Gastroenterol Rep (Oxf). 2017 May;5(2):127-137. doi: 10.1093/gastro/gox009. Epub 2017 Apr 24.
PMID: 28533910BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Doctor
Study Record Dates
First Submitted
September 15, 2018
First Posted
September 18, 2018
Study Start
May 1, 2021
Primary Completion
December 31, 2021
Study Completion
January 31, 2022
Last Updated
February 24, 2021
Record last verified: 2021-02