Role of ICCO Score in Predicting Outcome in ICU Patients

NCT06561477 | Completed

• 1 other identifier: ICCO score
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims at calculating a specific score to cirrhotic patients admitted at ICU (ICCO score) and use this score to predict mortality and outcome for admitted patients.

Conditions

Liver Cirrhosis

Outcome Measures

Primary Outcomes (1)

• Testing the validity of ICCO score in predicting mortality in critically ill patients with cirrhosis admitted to the ICU.

  ICCO score will be calculated to all participants based on the formula The ICCO score was 0.3707 + (0.0773 x bilirubin (mg/dl)) - (0.00849 x cholesterol (mg/dl)) -(0.0155 x creatinine clearance (ml/min)) + (0.1351 x lactate (mmol/l)). and then correlation between ICCO score and ICU mortality will be tested

  baseline

Secondary Outcomes (3)

• Compare ICCO score with other established ICU scoring systems regarding their ability to predict mortality in ICU cirrhotic patients.

  baseline

• Evaluate the utility of ICCO score in guiding clinical decision-making and resource allocation in ICU settings.

  baseline

• Assess the correlation of ICCO score with severity of liver disease and other organ dysfunctions.

  baseline

Interventions

Intensive care cirrhosis outcome (ICCO) score OTHER

ICCO score will be calculated for the participants to use it as a predictor for mortality and ICU outcome The ICCO score is 0.3707 + (0.0773 x bilirubin (mg/dl)) - (0.00849 x cholesterol (mg/dl)) -(0.0155 x creatinine clearance (ml/min)) + (0.1351 x lactate (mmol/l))

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with confirmed diagnosis with liver cirrhosis admitted to the intensive care unit

You may qualify if:

• Adult patients (age ≥18 years) with cirrhosis admitted to the ICU.
• Confirmed diagnosis of cirrhosis based on clinical, radiological, and/or histological criteria.
• Need for intensive care management due to acute illness or complications related to cirrhosis.

You may not qualify if:

• Patients without a confirmed diagnosis of cirrhosis.
• Patients with acute liver failure not meeting criteria for cirrhosis.
• Patients with incomplete data for calculating ICCO.
• Patients transferred from another ICU.
• Patients who refuse participation in the study.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university hospitals

Asyut, Egypt

Location

Related Publications (6)

• Zauner C, Schneeweiss B, Schneider B, Madl C, Klos H, Kranz A, Ratheiser K, Kramer L, Lenz K. Short-term prognosis in critically ill patients with liver cirrhosis: an evaluation of a new scoring system. Eur J Gastroenterol Hepatol. 2000 May;12(5):517-22. doi: 10.1097/00042737-200012050-00007.

  PMID: 10833094 BACKGROUND

• Gumilas NSA, Widodo I, Ratnasari N, Heriyanto DS. Potential relative quantities of miR-122 and miR-150 to differentiate hepatocellular carcinoma from liver cirrhosis. Noncoding RNA Res. 2022 Feb 6;7(1):34-39. doi: 10.1016/j.ncrna.2022.01.004. eCollection 2022 Mar.

  PMID: 35224317 BACKGROUND

• Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, Loomba R. Global epidemiology of cirrhosis - aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol. 2023 Jun;20(6):388-398. doi: 10.1038/s41575-023-00759-2. Epub 2023 Mar 28.

  PMID: 36977794 BACKGROUND

• Abdellatif Z, Eletreby R, Samir R, Abdallah M, Lithy R, Zayed N. Outcome and prognostic markers of cirrhotic and non-cirrhotic patients admitted to a hepatology ICU in a tertiary care university hospital. Afr Health Sci. 2022 Jun;22(2):377-383. doi: 10.4314/ahs.v22i2.43.

  PMID: 36407342 BACKGROUND

• da Silveira F, Soares PHR, Marchesan LQ, da Fonseca RSA, Nedel WL. Assessing the prognosis of cirrhotic patients in the intensive care unit: What we know and what we need to know better. World J Hepatol. 2021 Oct 27;13(10):1341-1350. doi: 10.4254/wjh.v13.i10.1341.

  PMID: 34786170 BACKGROUND

• Elzouki AN, Suliman S, Alhasan R, Abdullah A, Othman M, Badi A. Predicting mortality of patients with cirrhosis admitted to medical intensive care unit: An experience of a single tertiary center. Arab J Gastroenterol. 2016 Dec;17(4):159-163. doi: 10.1016/j.ajg.2016.11.003. Epub 2016 Dec 15.

  PMID: 27988236 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: August 9, 2024
• First Posted: August 20, 2024
• Study Start: March 1, 2025
• Primary Completion: January 2, 2026
• Study Completion: February 6, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Locations

EG (1)