Sympathetic Stress and Whole Body Vibration Reflex

NCT05478447 | Completed

• 1 other identifier: SSTWBVR
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

Whole body vibration (WBV) is a therapeutic modality in the form of exercise on a vibrating platform with an amplitude of 2-4 mm at a frequency of 25-50 Hz, which is used with increased popularity in sports medicine and rehabilitation due to its beneficial effects on muscle strength, balance, postural control, bone formation, and circulation. Beneficial effects on muscle strength and athletic performance have been reported. Spinal reflexes explain these beneficial neuromuscular effects. However, the neuronal circuit and receptors of the reflex response have not been defined precisely. A group of researchers propose that the reflex system underlying the neuromuscular effects of WBV is the Tonic vibration reflex (TVR), whose receptor is the muscle spindle; other researchers claim that the reflex latency induced by WBV is 4-5 ms longer than the TVR latency, so it is a bone myoregulation reflex whose receptor is osteocytes. The muscle spindle has sympathetic innervation. It has been reported that in case of increased sympathetic activity, muscle spindle sensitivity may increase and short-latency stretch reflex may be facilitated. The variation of muscle spindle activity with sympathetic activity may provide an opportunity to define the nature of the reflex response during WBV. Muscle spindles are more sensitive to vibrations around 100 Hz. This study has two hypotheses: According to the first hypothesis, WBV activates muscle spindles and the reflex latency induced by WBV is the same as TVR latency, and the latency does not change with increased sympathetic activity. According to the alternative hypothesis, WBV activates osteocytes, and WBV-induced reflex latency is longer than TVR latency. With increased sympathetic activity, the WBV reflex becomes dominant and the WBV-induced reflex latency becomes shorter. The aim of this research is to determine which of these two hypotheses is valid.

Conditions

Vibration; Exposure; Muscle Physiology

Keywords

tonic vibration reflex; vibration; whole body vibration; sympathetic activation

Outcome Measures

Primary Outcomes (2)

• Whole-body vibration (WBV) induced reflex latency

  Latency of the soleus reflex response induced by WBV. Its unit is milliseconds

  during intervention, an average of 3 minute

• Tendon vibration induced reflex latency

  Vibration will be applied to the achilles tendon. The soleus reflex latency induced by the tendon vibration will be measured. Its unit is milliseconds

  during intervention, an average of 3 minute

Secondary Outcomes (2)

• Heart rate variability

  during intervention, an average of 2 hours

• Sympathetic skin response

  during intervention, an average of 2 hours

Study Arms (1)

Vibration group

EXPERIMENTAL

Vibration (WBV, and tendon vibration) and sympathetic activation maneuvers will be applied to participants

Procedure: Vibration

Interventions

Vibration PROCEDURE

whole-body vibration, and tendon vibrations will be applied to the human body

Also known as: whole body vibration, tendon vibration, sympathetic activation maneuver

Vibration group

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being healthy
• Being a young adult (20-45 years old)
• Volunteer
• Male

You may not qualify if:

• Scar, dermatitis, etc. in the skin tissue where EMG electrodes will be placed
• Kidney stone history
• Fracture in the lower extremity, history of orthopedic surgery
• Heart disease, Hypertension
• Dizziness
• Metabolic bone diseases, including osteoporosis
• History of bone occupying lesion, neoplasia, osteomyelitis
• Degenerative, inflammatory diseases of the joints of the lower extremities
• Lower extremity thrombophlebitis
• Lower extremity motor loss, sensory loss, muscle atrophy
• Cold allergy
• Subjects who cannot tolerate whole-body vibration

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training & Research Hospital

Istanbul, 34173, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Vibration

Intervention Hierarchy (Ancestors)

Mechanical Phenomena; Physical Phenomena

Study Officials

• İlhan Karacan, Assoc Prof

  Istanbul Physical Medicine Rehabilitation Training & Research Hospital

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 26, 2022
• First Posted: July 28, 2022
• Study Start: September 9, 2022
• Primary Completion: September 29, 2022
• Study Completion: September 30, 2022
• Last Updated: October 13, 2022

Record last verified: 2022-10

Locations

TU (1)