Evaluation of the Strength of Handgrip in Patients With Pulmonary Artery Hypertension

NCT05447390 | Unknown

• 1 other identifier: 2022-397
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Our study aims to investigate the changes in muscle strength and muscle mass in PAH patients compared to healthy individuals and determine its effects on prognosis. Further categorization of PAH patients based on their NYHA class will help determine if their handgrip strength decreases while progressing from NYHA class 1 to 4. This in turn allows us to examine if the handgrip test can be considered as an alternative to a 6-minute walking test (6MWT). The Jamar Hydraulic Hand Dynamometer device in our hospital is used for measuring the handgrip strength test. The data of the included subjects in this study are obtained and recorded from the existing files. Also, the handgrip strength test data will be recorded after the investigation

Conditions

Pulmonary Hypertension

Keywords

handgrip; functional status

Outcome Measures

Primary Outcomes (1)

• Evaluation of the strength of handgrip in patients with pulmonary artery hypertension

  Investigate and evaluate of the strength of handgrip in patients with pulmonary artery hypertension with hand dynamometer compared to healthy individuals.

  Baseline

Secondary Outcomes (1)

• Evaluation of the strength of handgrip in patients with pulmonary artery hypertension

  Baseline

Study Arms (2)

Pulmonary Hypertension

ACTIVE COMPARATOR

Diagnostic Test: Handgrip strength test

Healthy Control

ACTIVE COMPARATOR

Diagnostic Test: Handgrip strength test

Interventions

Handgrip strength test DIAGNOSTIC_TEST

The Jamar Hydraulic Hand Dynamometer device is used for measuring the handgrip strength test

Healthy Control; Pulmonary Hypertension

Eligibility Criteria

• Age: 5 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Pulmonary Hypertension Group:
• Diagnosed with Pulmonary Hypertension and attending the clinic for follow-ups.
• Older than 5 years.
• Healthy Control Group
• Individuals without any known diseases, structural Cardiac anomalies, familial history of heart diseases and sudden death.
• Older than 5 years.

You may not qualify if:

• Volunteers' Rejection Criteria:
• Younger than 5 years.
• Mental state disorders which will cause inaccuracies in the study's
• i. Volunteers' Dismissal Criteria:
• Inadaptation to the study's steps.
• If subjects become reluctant to continue with the study.

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University School of Medicine

Ankara, 06560, Turkey (Türkiye)

Location

Related Publications (7)

• Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wahlander H, Weber SC, Zartner P. 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT. J Heart Lung Transplant. 2019 Sep;38(9):879-901. doi: 10.1016/j.healun.2019.06.022. Epub 2019 Jun 21.

  PMID: 31495407 BACKGROUND

• Kula S, Pektas A. A review of pediatric pulmonary hypertension with new guidelines. Turk J Med Sci. 2017 Apr 18;47(2):375-380. doi: 10.3906/sag-1605-172.

  PMID: 28425226 BACKGROUND

• Di Rienzo A, Felicetti L, Novelletto A, Forteleoni G, Colombo B. Frequency and types of deletional alpha+-thalassemia in northern Sardinia. Hum Genet. 1985;71(2):147-9. doi: 10.1007/BF00283371.

  PMID: 2995236 BACKGROUND

• Neidenbach RC, Oberhoffer R, Pieper L, Freilinger S, Ewert P, Kaemmerer H, Nagdyman N, Hager A, Muller J. The value of hand grip strength (HGS) as a diagnostic and prognostic biomarker in congenital heart disease. Cardiovasc Diagn Ther. 2019 Oct;9(Suppl 2):S187-S197. doi: 10.21037/cdt.2019.09.16.

  PMID: 31737527 BACKGROUND

• Mathiowetz V, Wiemer DM, Federman SM. Grip and pinch strength: norms for 6- to 19-year-olds. Am J Occup Ther. 1986 Oct;40(10):705-11. doi: 10.5014/ajot.40.10.705.

  PMID: 3777107 BACKGROUND

• Hager-Ross C, Rosblad B. Norms for grip strength in children aged 4-16 years. Acta Paediatr. 2002;91(6):617-25. doi: 10.1080/080352502760068990.

  PMID: 12162590 BACKGROUND

• Ploegmakers JJ, Hepping AM, Geertzen JH, Bulstra SK, Stevens M. Grip strength is strongly associated with height, weight and gender in childhood: a cross sectional study of 2241 children and adolescents providing reference values. J Physiother. 2013 Dec;59(4):255-61. doi: 10.1016/S1836-9553(13)70202-9.

  PMID: 24287219 BACKGROUND

MeSH Terms

Conditions

Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D, Professor

Model Details: This study includes 15 patients diagnosed with Pulmonary Hypertension in Gazi Medical School Hospital Department of Pediatric Cardiology and 40 healthy children who applied to Gazi University Medical School Pediatric Cardiology Clinic

Study Record Dates

• First Submitted: June 28, 2022
• First Posted: July 7, 2022
• Study Start: September 1, 2020
• Primary Completion: May 1, 2023
• Study Completion: June 1, 2023
• Last Updated: July 7, 2022

Record last verified: 2022-07

Locations

TU (1)