TMS Alteration of the Reward Positivity

NCT05443256 | Completed Results DMC FDA Device

• 1 other identifier: 20071
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this proposal is to demonstrate that stimulation of different brain regions differently affects the electroencephalographic feature known as the Reward Positivity (RewP).

Conditions

Anhedonia

Outcome Measures

Primary Outcomes (1)

• Reward Positivity

  EEG Amplitude 200-400 ms following reward receipt

  During intervention

Study Arms (2)

Theta Stim

EXPERIMENTAL

To stimulate fMRI-informed individualized targets in dlPFC to diminish affective modulation of the RewP. Based on our working hypothesis, TMS Figure-8 coil stimulation should diminish affective modulation of RewP amplitude when compared to sham.

Device: Transcranial Magnetic Stimulation

Sham Stim

SHAM COMPARATOR

Sham stimulation. The Reward Positivity should be unaffected.

Device: Transcranial Magnetic Stimulation

Interventions

Transcranial Magnetic Stimulation DEVICE

Figure 8 coil stimulation

Sham Stim; Theta Stim

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men or women aged 18-30

You may not qualify if:

• Participants unwilling or unable to give informed consent
• Presence of other known medical or psychiatric comorbidity that in the investigator's opinion would compromise participation in the study
• MEG/MRI contraindications
• History of psychosis
• Not fluent in English

Sponsors & Collaborators

• University of New Mexico: lead

Study Sites (1)

University of New Mexico - Logan hall

Albuquerque, New Mexico, 87106, United States

Location

MeSH Terms

Conditions

Anhedonia

Interventions

Transcranial Magnetic Stimulation

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Results Point of Contact

• Title: Dr. James F. Cavanagh
• Organization: University of New Mexico

jcavanagh@unm.edu

5052773890

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Two separate arms of study

Study Record Dates

• First Submitted: June 29, 2022
• First Posted: July 5, 2022
• Study Start: August 1, 2022
• Primary Completion: November 17, 2023
• Study Completion: October 17, 2024
• Last Updated: December 10, 2024
• Results First Posted: December 10, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)