Translational Model of Anhedonia

NCT03856177 | Completed Results

• 1 other identifier: 1R01MH119382-01
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed research addresses a major mental health issue (anhedonia) with a novel computationally-inspired translational technique in both humans and mice. This approach greatly increases the likelihood that a positive animal model result will be successfully translated to humans. This research plan thus offers a novel way to address the NIMH's mission of defining mechanisms of complex behaviors.

Conditions

Anhedonia

Outcome Measures

Primary Outcomes (1)

• Reward Positivity Component of the Event-Related Electroencephalogram

  The Reward Positivity is a fronto-centrally located positive voltage burst recorded in the EEG from about 200-500 ms following the receipt of a reinforcing outcome (e.g. money, points). Higher voltages (more positive numbers) indicate a larger reward response.

  There will only be one day session (on the date of the randomization) where the Reward Positivity amplitude is assessed

Study Arms (2)

Neutral

EXPERIMENTAL

A neutral mood induction will include reading a dull text while listening to non-evocative music for 5-15 minutes.

Behavioral: Emotion Induction

Evocative

EXPERIMENTAL

A mood induction procedure will be utilized. The procedure consists of a combination of re-experiencing an autobiographical sad personal event while listening to their choice of one of four sad music selections commonly used in mood induction. Visual analogue scale ratings will assess momentary sadness prior to, following, and at subsequent time points around the mood induction procedure.

Behavioral: Emotion Induction

Interventions

Emotion Induction BEHAVIORAL

Described in arm

Evocative; Neutral

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men or women aged 18-55
• Free from psychoactive medication for at least 2 weeks

You may not qualify if:

• Participants unwilling or unable to give informed consent
• Presence of other known medical or psychiatric comorbidity that in the investigator's opinion would compromise participation in the study
• History of psychosis
• Not fluent in English

Sponsors & Collaborators

• University of New Mexico: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

University of New Mexico - Logan hall

Albuquerque, New Mexico, 87106, United States

Location

MeSH Terms

Conditions

Anhedonia

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. James F. Cavanagh
• Organization: University of New Mexico

jcavanagh@unm.edu

4158670303

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Randomization will be based on the last digit (odd vs. even) of the participant's research identifier.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be randomly assigned into neutral or emotionally evocative conditions prior to assessing EEG brain signals of reward.

Study Record Dates

• First Submitted: February 21, 2019
• First Posted: February 27, 2019
• Study Start: April 1, 2019
• Primary Completion: July 1, 2021
• Study Completion: July 1, 2021
• Last Updated: March 29, 2024
• Results First Posted: April 24, 2023

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)