Functional Organization of the Superior Temporal Gyrus for Speech Perception

NCT05435859 | Enrolling By Invitation

• 1 other identifier: R01DC012379
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The basic mechanisms underlying comprehension of spoken language are still largely unknown. Over the past decade, the study team has gained new insights to how the human brain extracts the most fundamental linguistic elements (consonants and vowels) from a complex and highly variable acoustic signal. However, the next set of questions await pertaining to the sequencing of those auditory elements and how they are integrated with other features, such as, the amplitude envelope of speech. Further investigation of the cortical representation of speech sounds can likely shed light on these fundamental questions. Previous research has implicated the superior temporal cortex in the processing of speech sounds, but little is known about how these sounds are linked together into the perceptual experience of words and continuous speech. The overall goal is to determine how the brain extracts linguistic elements from a complex acoustic speech signal towards better understanding and remediating human language disorders.

Conditions

Epilepsy; Brain Tumor; Speech

Outcome Measures

Primary Outcomes (1)

• Number of Participants with Electrocorticography (ECoG) Signals for Neural Activity Identified During Intraoperative Procedure or Inpatient Hospitalization

  Number of participants with ECoG signals for neural activity identified during intraoperative procedure or inpatient hospitalization, between 10-30 minutes.

  During Procedure

Study Arms (1)

Electrocorticography (ECoG) recording during Speech Tasks

EXPERIMENTAL

Participants listened to 25-minute Speech Tasks while ECoG signals for neural activity was recorded during their intraoperative procedure or inpatient hospitalization at the University of California, San Francisco (UCSF).

Behavioral: Speech Tasks

Interventions

Speech Tasks BEHAVIORAL

Listen to 25-minutes of speech sounds in English.

Electrocorticography (ECoG) recording during Speech Tasks

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants with epilepsy or brain tumors at UCSF undergoing surgical electrode implantation for seizure localization or awake intraoperative brain mapping for resection of brain tumors or epilepsy and
• Participants with electrodes implanted in at least two regions of interest who are willing and able to cooperate with study tasks.

You may not qualify if:

• Participants who lack capacity or decline to provide informed consent,
• Participants who have significant cerebral lesions or
• Participants with cognitive deficits that preclude reliable completion of study tasks.

Sponsors & Collaborators

• University of California, San Francisco: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator
• University of California, Berkeley: collaborator

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94143, United States

Location

MeSH Terms

Conditions

Epilepsy; Brain Neoplasms; Speech

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Verbal Behavior; Communication; Behavior

Study Officials

• Edward F Chang, MD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 22, 2022
• First Posted: June 28, 2022
• Study Start: August 16, 2022
• Primary Completion (Estimated): July 31, 2027
• Study Completion (Estimated): July 31, 2027
• Last Updated: June 8, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)