NCT05433389

Brief Summary

This will be a single-site, five-arm, parallel group randomized control trial involving patients undergoing knee or hip replacement surgery. The investigators will compare five different styles of 5-minute, audio-recoded mindfulness practices delivered via app 7 days before to surgery, 2 days before to surgery, 2 days after surgery, and 6 days after surgery.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
823

participants targeted

Target at P75+ for not_applicable pain

Timeline
Completed

Started Jun 2022

Longer than P75 for not_applicable pain

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 21, 2022

Completed
Same day until next milestone

Study Start

First participant enrolled

June 21, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 27, 2022

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 26, 2025

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2025

Completed
Last Updated

June 17, 2025

Status Verified

June 1, 2025

Enrollment Period

2.9 years

First QC Date

June 21, 2022

Last Update Submit

June 16, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Pain Unpleasantness

    Single item assessing pain unpleasantness ("How unpleasant is your pain?") scored on an 11-point (0=Not at all, 10=Very much) numeric rating scale. Higher scores indicate greater pain unpleasantness.

    Immediately before to after 5-minute audio recording

Secondary Outcomes (2)

  • Change in Pain Intensity

    Immediately before to after 5-minute audio recording

  • Change in Pain Medication Desire

    Immediately before to after 5-minute audio recording

Other Outcomes (3)

  • Change in Anxiety

    Immediately before to after 5-minute audio recording

  • Change in Depression

    Immediately before to after 5-minute audio recording

  • Postoperative Patient Reported Outcomes Measurement Information System (PROMIS) Physical Functioning Item Bank, v2.0

    During the 6 weeks prior to surgery and at the 6-week outpatient follow-up appointment

Study Arms (5)

Breath Counting

ACTIVE COMPARATOR
Behavioral: Breath Counting

Body Scan

EXPERIMENTAL
Behavioral: Body Scan

Mindful Breathing

EXPERIMENTAL
Behavioral: Mindful Breathing

Mindfulness of Pain

EXPERIMENTAL
Behavioral: Mindfulness of Pain

Mindful Savoring

EXPERIMENTAL
Behavioral: Mindful Savoring

Interventions

Breath CountingBEHAVIORAL

Patients will listen to a 5-minute, audio-recorded breath counting practice.

Breath Counting
Body ScanBEHAVIORAL

Patients will listen to a 5-minute, audio-recorded body scan practice.

Body Scan

Patients will listen to a 5-minute, audio-recorded mindful breathing practice.

Mindful Breathing

Patients will listen to a 5-minute, audio-recorded mindfulness of pain practice.

Mindfulness of Pain

Patients will listen to a 5-minute, audio-recorded mindful savoring practice.

Mindful Savoring

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥18,
  • Scheduled to undergo total joint arthroplasty of the knee or hip

You may not qualify if:

  • Inability to read English
  • Cognitive impairment preventing completion of study procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Utah

Salt Lake City, Utah, 84112, United States

Location

MeSH Terms

Conditions

PainAnxiety DisordersDepression

Interventions

Whole Body Imaging

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMental DisordersBehavioral SymptomsBehavior

Intervention Hierarchy (Ancestors)

Diagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisInvestigative Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

June 21, 2022

First Posted

June 27, 2022

Study Start

June 21, 2022

Primary Completion

May 26, 2025

Study Completion

November 1, 2025

Last Updated

June 17, 2025

Record last verified: 2025-06

Locations