NCT04800354

Brief Summary

This is a single-site, two-arm, parallel-group randomized clinical trial (RCT). The feasibility, acceptability, and clinical effects of the nurse-led, very brief, preoperative mindfulness based intervention for hip and knee replacement patients will be investigated relative to nurse-led preoperative pain psychoeducation. A secondary sub-analysis will compare two different styles of mindfulness practice (mindfulness of breath vs. mindfulness of pain) relative to preoperative pain psychoeducation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
127

participants targeted

Target at P75+ for not_applicable pain

Timeline
Completed

Started Feb 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 22, 2021

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

March 7, 2021

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 16, 2021

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 20, 2021

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 10, 2022

Completed
Last Updated

January 11, 2022

Status Verified

January 1, 2022

Enrollment Period

3 months

First QC Date

March 7, 2021

Last Update Submit

January 10, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Pain Intensity Numeric Rating Scale

    Single Likert scale item ranging from 0-10, with 0 indicating no pain and 10 representing the most intense pain imaginable.

    baseline and after the 15 minute preoperative nurse visit

Secondary Outcomes (3)

  • Change in Pain Unpleasantness Numeric Rating Scale

    baseline and after the 15 minute preoperative nurse visit

  • Change in Pain Medication Desire Numeric Rating Scale

    baseline and after the 15 minute preoperative nurse visit

  • Postoperative Patient Reported Outcomes Measurement Information System (PROMIS) Physical Functioning Item Bank, v2.0

    During the 6 weeks prior to surgery and at the 6-week outpatient follow-up appointment

Study Arms (2)

Nurse-led Mindfulness Based Intervention

EXPERIMENTAL
Behavioral: Nurse-led Mindfulness Based InterventionBehavioral: Nurse-led Pain Psychoeducation

Nurse-led Pain Psychoeducation

ACTIVE COMPARATOR
Behavioral: Nurse-led Pain Psychoeducation

Interventions

Nurses will read patients a brief (1 minute) scripted, introduction to mindfulness and then have them listen to a very brief (1 minute 30 second) guided mindfulness practice validated in our prior research to encourage focused attention on breath and body sensations and open monitoring and acceptance of discursive thoughts, negative emotions, and pain. Finally, patients will be given an audio recording of the mindful pain management technique for use any time they experience intense pain or take pain medication before and after surgery.

Nurse-led Mindfulness Based Intervention

Nurses will provide psychoeducation about pain along with common pain coping strategies, such as rest, ice, and elevation, for use any time they experience intense pain or take pain medication before and after surgery.

Nurse-led Mindfulness Based InterventionNurse-led Pain Psychoeducation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \) Age ≥18,
  • \) Scheduled to undergo unilateral total knee arthroplasty

You may not qualify if:

  • \) Cognitive impairment preventing completion of study procedures.
  • \) Current cancer diagnosis,
  • \) Contralateral knee replaced in the previous 3 months,
  • \) Intent to have contralateral knee replaced or other, additional surgical procedure during the study period,
  • \) Intent to add new pain treatments during the study period (except for what is part of the study),
  • \) Other unstable illness judged by medical staff to interfere with study treatment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Utah

Salt Lake City, Utah, 84112, United States

Location

MeSH Terms

Conditions

PainOsteoarthritis, KneeOsteoarthritis, Hip

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsOsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

March 7, 2021

First Posted

March 16, 2021

Study Start

February 22, 2021

Primary Completion

May 20, 2021

Study Completion

January 10, 2022

Last Updated

January 11, 2022

Record last verified: 2022-01

Locations