Comparison of Motor Relearning and Neurodevelopmental Therapy in Stroke Patients

NCT05425082 | Completed

• 1 other identifier: REC/RCR&AHS/22/0225
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to find out the comparison of motor relearning and neurodevelopmental therapy on motor performance and quality of life in stroke patients.As motor relearning program and neurodevelopmental therapy have different effects on lower limb motor functions and quality of life. Therefore, there is need to find out the best treatment approach either MRP, neurodevelopmental therapy or both to improve motor function of lower limb and quality of life as it will help the patient to gain functional independency. This study will provide the health professionals the evidence to use these techniques according to patient interest in the clinical setup.

Conditions

Stroke

Keywords

Stroke

Outcome Measures

Primary Outcomes (3)

• Fugl Meyer Assessment Scale

  Use: The Fugl-Meyer Assessment (FMA) is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, balance, sensation and joint functioning in patients with post-stroke hemiplegia.

  6th week

• Modified Barthel Index

  Use: The MBI was used to measure functional performance in basic activities of daily living (ADL).

  6th week

• TIME UP AND GO TEST

  Use: The 'timed up and go' test (TUG) is a simple, quick and widely used clinical performance-based measure of lower extremity function, mobility and fall risk.

  6th week

Study Arms (2)

Motor relearning program

ACTIVE COMPARATOR

Emphasis of MRP is on practice of specific activities, the training of cognitive control over muscles \& movement. Components of activities \& conscious elimination of unnecessary muscle activity.• Based on 3 factors - 1. Elimination of unnecessary muscle activity 2. Feedback 3. Practice

Other: Motor relearning program

Neurodevelopmental therapy

EXPERIMENTAL

The abnormal patterns must be stopped not by modifying the sensory input, but by giving back to the patient the • The hemiplegic side should be incorporated into all treatment activities to reestablish symmetry and increased functional use * Treatment should produce a change in the quality of movement and functional performance of the involved side * Increase active use of the involved side * Provide practice to improve motor performance that led to motor learning lost or undeveloped control over his output in developmental sequence

Other: Neurodevelopmental therapy

Interventions

Motor relearning program OTHER

Treatment session of one hour per day for five days a week, for four weeks for each participant until 20 sessions

Motor relearning program

Neurodevelopmental therapy OTHER

Treatment session of one hour per day for five days a week, for four weeks for each participant until 20 sessions.

Neurodevelopmental therapy

Eligibility Criteria

• Age: 45 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both male and female, with age between 45-70 years
• First-time unilateral stroke confirmed by magnetic resonance imaging or computed axial tomography scan.
• Clinically stable with fully oriented and conscious.
• Subacute stroke patients.
• Patients having lower limb dysfunction.
• Patients with Mini Mental State Examination MMSE score ≥ 24

You may not qualify if:

• Recurrent stroke.
• Foot drop
• Cardiac disease that limit function by exertional dyspnea, angina or severe fatigue.
• Any visual and hearing problem
• Subarachnoid or extradural hemorrhage, progressive hydrocephalus, previous history of brain injury

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Chughtai Rehabilitation Centre

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (12)

• Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015 Mar 12;372(11):1019-30. doi: 10.1056/NEJMoa1414905. Epub 2015 Feb 11.

  PMID: 25671798 BACKGROUND

• Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet. 2011 May 14;377(9778):1693-702. doi: 10.1016/S0140-6736(11)60325-5.

  PMID: 21571152 BACKGROUND

• Ng YS, Stein J, Ning M, Black-Schaffer RM. Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories. Stroke. 2007 Aug;38(8):2309-14. doi: 10.1161/STROKEAHA.106.475483. Epub 2007 Jul 5.

  PMID: 17615368 BACKGROUND

• Ernst E. A review of stroke rehabilitation and physiotherapy. Stroke. 1990 Jul;21(7):1081-5. doi: 10.1161/01.str.21.7.1081.

  PMID: 2195716 BACKGROUND

• Chan DY, Chan CC, Au DK. Motor relearning programme for stroke patients: a randomized controlled trial. Clin Rehabil. 2006 Mar;20(3):191-200. doi: 10.1191/0269215506cr930oa.

  PMID: 16634338 BACKGROUND

• Sheffler LR, Taylor PN, Gunzler DD, Buurke JH, Ijzerman MJ, Chae J. Randomized controlled trial of surface peroneal nerve stimulation for motor relearning in lower limb hemiparesis. Arch Phys Med Rehabil. 2013 Jun;94(6):1007-14. doi: 10.1016/j.apmr.2013.01.024. Epub 2013 Feb 8.

  PMID: 23399456 BACKGROUND

• Hafsteinsdottir TB, Algra A, Kappelle LJ, Grypdonck MH; Dutch NDT Study Group. Neurodevelopmental treatment after stroke: a comparative study. J Neurol Neurosurg Psychiatry. 2005 Jun;76(6):788-92. doi: 10.1136/jnnp.2004.042267.

  PMID: 15897499 BACKGROUND

• Rudberg AS, Berge E, Laska AC, Jutterstrom S, Nasman P, Sunnerhagen KS, Lundstrom E. Stroke survivors' priorities for research related to life after stroke. Top Stroke Rehabil. 2021 Mar;28(2):153-158. doi: 10.1080/10749357.2020.1789829. Epub 2020 Jul 5.

  PMID: 32627722 BACKGROUND

• Pathak A, Gyanpuri V, Dev P, Dhiman NR. The Bobath Concept (NDT) as rehabilitation in stroke patients: A systematic review. J Family Med Prim Care. 2021 Nov;10(11):3983-3990. doi: 10.4103/jfmpc.jfmpc_528_21. Epub 2021 Nov 29.

  PMID: 35136756 BACKGROUND

• Yeh CY, Schulien AJ, Molyneaux BJ, Aizenman E. Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection. Int J Mol Sci. 2020 Aug 25;21(17):6107. doi: 10.3390/ijms21176107.

  PMID: 32854248 BACKGROUND

• Oyake K, Suzuki M, Otaka Y, Tanaka S. Motivational Strategies for Stroke Rehabilitation: A Descriptive Cross-Sectional Study. Front Neurol. 2020 Jun 10;11:553. doi: 10.3389/fneur.2020.00553. eCollection 2020.

  PMID: 32587572 BACKGROUND

• Pandian S, Arya KN, Davidson EWR. Comparison of Brunnstrom movement therapy and Motor Relearning Program in rehabilitation of post-stroke hemiparetic hand: a randomized trial. J Bodyw Mov Ther. 2012 Jul;16(3):330-337. doi: 10.1016/j.jbmt.2011.11.002. Epub 2011 Dec 6.

  PMID: 22703742 BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Binash Afzal, PHD*

  Riphah international university lahore campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2022
• First Posted: June 21, 2022
• Study Start: April 4, 2022
• Primary Completion: September 15, 2022
• Study Completion: November 15, 2022
• Last Updated: January 30, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)