Adaptation of the Motor System to Experimental Pain

NCT05396820 | Completed

• 1 other identifier: 2022-A00271-42
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to measure the impact of an experimental pain on electromyography, kinematics of motion and motor cortical excitability.

Conditions

Kinesiophobia; Pain, Acute

Keywords

kinesiophobia; experimental pain; corticospinal excitability; motor control; CUSOM

Outcome Measures

Primary Outcomes (2)

• Corticospinal excitability

  It will be measured using transcranial magnetic stimulation at different intensities in order to model I/O curves for each participant. Measurements will be taken before (pain-free condition) and after (pain condition) the application of a patch of capsaicin 1%, at the shoulder. Electromyographic signals, induced by the magnetic stimuli, will be captured with surface electrodes glued to the skin the anterior deltoid and upper trapezius muscles. To facilitate obtaining deltoid MEPs, participants will be asked to voluntarily contract 8-12% of their maximum voluntary contraction. The Boltzmann sigmoidal function will be used to fit the data points to construct the I/O curves. The mathematical modeling of the I/O curves allows the calculation of three parameters: the slope, the plateau, and the S50, the intensity allowing to obtain a response twice less than the maximum response. These 3 parameters will be used to compare them with the 2 conditions (before and after pain).

  1 hour

• Kinesiophobia

  Kinesiophobia will be assessed using the French-Canadian version of the Tampa Kinesiophobia Questionnaire (EKT-CF). It takes the form of a self-reported questionnaire of 17 items using a Likert scale ranging from 1 (strongly disagree) to 4 (strongly agree), with an acceptable degree of internal consistency (Cronbach's alpha = 0.71), satisfactory construct validity, and high sensitivity to change (intra-class correlation coefficient \> 0.7). The total score is obtained by adding the value of the responses and is between 17 and 68. The value of 40/68 is considered as the threshold value at which kinesiophobia becomes significant.

  5 minutes

Secondary Outcomes (6)

• Activation synergies

  1 hour

• Kinematic parameters: Linearity of motion

  1 hour

• Kinematic parameters: Smoothness of motion

  1 hour

• Kinematic parameters: Maximum directional error

  1 hour

• EMG data and cumulative summation: The area of the puffs

  1 hour

Study Arms (1)

Experimental pain

EXPERIMENTAL

Experimental pain will be induced at the level of the dominant delto-pectoral groove of the participant (between the shoulder stump and the pectoral).

Other: Experimental pain

Interventions

Experimental pain OTHER

Experimental pain will be induced by capsaicin 1% on intact, non-irritated and dry shoulder's skin. For the purposes of this study, we will remove this patch before the recommended application time in order to generate a pain. The participant will be seated on a chair facing a table so that his or her dominant forearm rests on the table. Markers will be placed at the table and chair legs as well as on the table, corresponding to the two support points of the elbow and the index finger, in order to standardize the starting position. The target of the pointing movement will be placed at 80% of this maximum distance. The investigator will tell the participant to stand by, and then, within 4 to 10 seconds, an audible signal will indicate to the subject that he/she should perform the pointing movement. The procedure will repeat after a 4-10 second pause. For each session, 30 pointing movements reaching the target will be performed.

Experimental pain

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects (who do not have self-reported neurological disorders)
• Subjects who have signed an informed consent (who have a good command of French)
• Subjects affiliated with or receiving social security benefits

You may not qualify if:

• Psychiatric history obtained through physician questioning: individuals with mental retardation or severe impairment of cognitive, behavioral, or emotional function that precludes understanding the protocol and signing informed consent
• Neurological history (epilepsy, stroke, surgeries performed on the brain or spinal cord, and history of neurological diseases affecting motor skills and sensation)
• Subjects who are unable to receive informed information (dementia, hearing problems, poor French proficiency, etc.)
• Contraindications to MST (epilepsy, intracranial metal foreign bodies, hearing aids or cochlear implants)
• Taking psychotropic medications
• Persons under guardianship or conservatorship
• Pregnant and nursing women
• Subjects with pacemakers

Sponsors & Collaborators

• Universite du Littoral Cote d'Opale: lead

Study Sites (1)

Eurasport

Loos, Nord, 59120, France

Location

Related Publications (1)

• Duport A, Morel P, Leonard G, Devanne H. The influence of pain and kinesiophobia on motor control of the upper limb: how pointing task paradigms can point to new avenues of understanding. Pain. 2024 Sep 1;165(9):2044-2054. doi: 10.1097/j.pain.0000000000003213. Epub 2024 Mar 13.

  PMID: 38501987 DERIVED

MeSH Terms

Conditions

Kinesiophobia; Acute Pain

Condition Hierarchy (Ancestors)

Phobic Disorders; Anxiety Disorders; Mental Disorders; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: A randomized number is allocated for all participants.
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Cross sectional study

Study Record Dates

• First Submitted: May 18, 2022
• First Posted: May 31, 2022
• Study Start: September 5, 2022
• Primary Completion: October 28, 2022
• Study Completion: October 31, 2023
• Last Updated: May 16, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)