Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

NCT05372731 | Unknown

• 1 other identifier: BAL20220420
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.

Conditions

Acute Respiratory Distress Syndrome

Outcome Measures

Primary Outcomes (1)

• the ratio of tidal volume in the BAL side and the other side

  distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side

  up to 24 hours

Secondary Outcomes (2)

• partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio

  up to 24 hours

• respiratory system compliance (the tidal volume to the driving pressure ratio)

  up to 24 hours

Study Arms (2)

RM after BAL

EXPERIMENTAL

patients underwent RM after BAL

Other: Recruitment Maneuver

Non-RM after BAL

NO INTERVENTION

patients did not undergo RM after BAL

Interventions

Recruitment Maneuver OTHER

RM after BAL

RM after BAL

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients with invasive mechanical ventilation;
• Patients who diagnosed with ARDS according to the Berlin definition
• There are indications for bronchoalveolar lavage

You may not qualify if:

• Patients with contraindications for EIT procedures;
• Patients with contraindications for RM;
• Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD);
• Pregnancy;
• Refusal to sign informed consent

Sponsors & Collaborators

• Southeast University, China: lead

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Officials

• ling liu, phD

  Zhongda Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ling liu, phD

CONTACT

86-25-83272201; liulingdoctor@126.com

ling liu, phD

CONTACT

86-25-83272201

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Intensive Care Unit, Principal Investigator, Clinical Professor

Study Record Dates

• First Submitted: April 20, 2022
• First Posted: May 13, 2022
• Study Start: November 30, 2022
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2022
• Last Updated: October 28, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share