Open Suction vs. Closed Suction in ARDS

NCT05537974 | Completed

• 1 other identifier: IGHCEAH-ICU-7
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The alveoli tend to collapse in patients with ARDS. Endotracheal aspiration may increase alveolar collapse by decreasing the end-expiratory lung volume. The hypothesis is that closed endotracheal aspiration led to less end-expiratory volume loss when compared to open endotracheal aspiration.

Conditions

Acute Respiratory Distress Syndrome

Keywords

Endotracheal aspiration, Electric impedance tomography

Outcome Measures

Primary Outcomes (1)

• End expiratory lung volume (EELV)

  End expiratory lung impedance (EELI) will be measured wit electric impedance tomography. Change in EELI representative of change in EELV.

  One minute before suctioning, 1, 10, 20, 30 minutes after suctioning

Study Arms (2)

Open Suction

OTHER

Endotracheal aspiration will perform after the patient disconnect from mechanical ventilation

Procedure: Endotracheal aspiration

Closed Suction

OTHER

Endotracheal aspiration will perform without disconnection from mechanical ventilation

Procedure: Endotracheal aspiration

Interventions

Endotracheal aspiration PROCEDURE

Clearance of endotracheal secretions via a catheter.

Closed Suction; Open Suction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mechanically ventilated due to ARDS

You may not qualify if:

• Hemodynamically unstable Air leaks syndrome (pneumothorax) Higher level of FiO2 (\>60%) Chronic obstructive pulmonary disease

Sponsors & Collaborators

• Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital: lead

Study Sites (1)

University of Health Sciences Turkey, Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Intensive Care Unit

Izmir, 35110, Turkey (Türkiye)

Location

Related Publications (1)

• Yildirim S, Saygili SM, Sunecli O, Kirakli C. Comparison of the effects of open and closed aspiration on end-expiratory lung volume in acute respiratory distress syndrome. Korean J Anesthesiol. 2024 Feb;77(1):115-121. doi: 10.4097/kja.23194. Epub 2023 May 22.

  PMID: 37211764 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Doctor

Model Details: This is a crossover study and suction procedure was made in a random order with 60 minutes wash out period between two suction maneuvers. Patients were randomized after intubation; randomization was made with sealed envelopes. All patients mechanically ventilated with lung protective ventilation strategy. Before the suctioning the patients ventilated with 100% of oxygen for 60 seconds. In open suction, the patient was disconnected from mechanical ventilator, the aspiration catheter advanced until resistance met after that the catheter withdraw 1 cm before aspiration. During endotracheal suctioning a negative pressure applied two times for 5 seconds. The negative pressure was set 150 mmHg. All suctioning maneuvers performed by intensivists.

Study Record Dates

• First Submitted: September 8, 2022
• First Posted: September 13, 2022
• Study Start: September 15, 2022
• Primary Completion: October 31, 2022
• Study Completion: October 31, 2022
• Last Updated: January 18, 2023

Record last verified: 2023-01

Locations

TU (1)