Exercise Target Brain Oscillations in Psychosis

NCT05338424 | Withdrawn

• 1 other identifier: PSYCH-2022-30666
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or "SIT". Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis. The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.

Conditions

Psychosis; Schizophrenia; Schizoaffective Disorder

Keywords

Psychosis; Schizophrenia; Schizoaffective Disorder; Exercise; Cognition; Attention

Outcome Measures

Primary Outcomes (3)

• Change in Individual Alpha Frequency

  A prominent neural oscillatory rhythm measured from resting EEG.

  through study completion, on average 2 weeks

• Change in Visual Attention

  Computerized tasks that measure speeded sustained attention.

  through study completion, on average 2 weeks

• Change in Visual Perception

  Computerized tasks that measure speeded visual perception

  through study completion, on average 2 weeks

Study Arms (2)

Sprint Interval Training (SIT)

The 1-session SIT protocol will include "Work" bouts performed at maximal intensity targets. Three "Work" bouts will be performed at 20-second intervals separated by 2 recovery bouts consisting of 2 minutes of low-intensity cycling. The SIT session will employ a standardized warm up and cool down of 3 minutes at a self-selected light intensity, per current guidelines. SIT sessions will take 15 minutes to complete.

Other: Sprint Interval Training (SIT)

Stretching

Stretching will include a low-intensity range of motion and stretching exercises with session duration (15 minutes) being matched to SIT.

Interventions

Sprint Interval Training (SIT) OTHER

Active arm-- exercise dictated by protocol

Sprint Interval Training (SIT)

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Individuals in good health with a psychotic disorder.

You may qualify if:

• Meet diagnostic criteria for schizophrenia or schizoaffective disorder
• Are age 18-64
• Fluent in written and spoken English
• Have an outpatient status of at least 1 month prior to participation
• Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators)

You may not qualify if:

• Current or possibility of current pregnancy (self-reported)
• Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS
• WTAR standardized score below 70
• American College of Sports Medicine contraindication to exercise

Sponsors & Collaborators

• University of Minnesota: lead

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

MeSH Terms

Conditions

Psychotic Disorders; Schizophrenia; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ian Ramsay

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 4, 2022
• First Posted: April 21, 2022
• Study Start: July 1, 2022
• Primary Completion: September 30, 2022
• Study Completion: September 30, 2022
• Last Updated: October 10, 2022

Record last verified: 2022-10

Locations

US (1)