Ethnic Variability in Glycemic and Hunger Satiety Response to Rice in Overweight Adults

NCT05336032 | Unknown

• 1 other identifier: SKMCA
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Evidence has./ indicated increased risk of type 2 diabetes with white rice consumption in Asian population. It is shown that glycemic response to carbohydrate-containing food may differ in people of different ethnicities. The large increment in glucose concentration induced by high glycemic index food often exaggerates the body's anabolic responses, which facilitates the overproduction of insulin and eventually results in pancreatic beta-cell failure, causing type 2 diabetes mellitus. Given that rice is the staple food of Asians and Emiratis, and extent to which rice influences postprandial glycemia could have potential relevance in the prevention and treatment of diabetes. In this study, the investigators intend to compare the glycemic and hunger satiety response to rice among overweight Emiratis, Asians, and Caucasian. The primary objective of the study is to compare the glycemic (glucose) and hunger satiety (hormone ghrelin and peptide YY) response to glucose and rice among overweight Emiratis, Asians, and Caucasians.

Conditions

Glycemic Response

Outcome Measures

Primary Outcomes (2)

• To compare the post prandial glucose response to oral glucose and rice among Emiratis, Asians, and Caucasian overweight adults

  post prandial glucose response at baseline, 30, 60, 120 minutes, oral glucose tolerance test (75 gm glucose) Vs. post prandial glucose response to rice test (75 gm available glucose)

  2 hours

• To compare the post prandial insulin response to oral glucose and rice among Emiratis, Asians, and Caucasian overweight adults

  post prandial insulin response at baseline, 30, 60, 120 minutes, oral glucose tolerance test (75 gm glucose) Vs. post prandial insulin response to rice test (75 gm available glucose)

  2 hours

Secondary Outcomes (2)

• To compare the post prandial hunger (ghrelin hormone) to oral glucose and rice among Asian, Emirati and European Caucasian overweight adults

  2 hours

• To compare the post prandial satiety (peptide-yy hormone) to oral glucose and rice among Asian, Emirati and European Caucasian overweight adults

  2 hours

Study Arms (2)

Oral glucose tolerance test

ACTIVE COMPARATOR

The volunteer will be performing the standardized oral glucose tolerance test with 75 gm of glucose. After an overnight fast of 10 hours the venous blood will be collected at fasting, 30, 60 and 120 minutes post-prandial and hunger-satiety scale recorded at the same interval.

Other: Food (rice)

Post prandial response to Rice

EXPERIMENTAL

The participants will be served cooked basmati rice (70-gram available glucose). After an overnight fast of 10 hours the venous blood will be collected at fasting, 30, 60 and 120 minutes post-prandial and hunger-satiety scale recorded at the same interval.

Other: Food (rice)

Interventions

Food (rice) OTHER

Cooked rice with 75 gm carbohydrate

Oral glucose tolerance test; Post prandial response to Rice

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants willing to comply with study procedures and given written consent
• Asian/Emirati/European ethnicity (both parents same ethnicity)
• Body mass index between 24.9-29.9 kg/m2
• Age 18-55 years
• Fasting blood glucose \<6.0 mmol/L

You may not qualify if:

• Subjects with chronic diseases, including diabetes, untreated hypertension, renal impairment, gastrointestinal problems, post bariatric, known eating disorders
• Use of medication affecting glucose metabolism
• Recent changes in weight of \> 5 % ove the past 3 months
• On antibiotics for the past 3 weeks

Sponsors & Collaborators

• Rashid Centre for Diabetes and Research: lead

Study Sites (1)

Rashid Centre for Diabetes and Research

Ajman, United Arab Emirates

RECRUITING

MeSH Terms

Interventions

Food

Intervention Hierarchy (Ancestors)

Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Central Study Contacts

Sadiya

CONTACT

00971637147345; sadiya.amena@gmail.com

Jakapure

CONTACT

00971637147387; vidya.jakapure@skmca.ae

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Manager Dietetics

Study Record Dates

• First Submitted: March 25, 2022
• First Posted: April 20, 2022
• Study Start: April 1, 2022
• Primary Completion: August 30, 2022
• Study Completion: October 30, 2022
• Last Updated: October 26, 2022

Record last verified: 2022-10

Locations

AE (1)