Prognostic Value of Effort-independent Cardiopulmonary Exercise Test Variables for Postoperative Complications After Elective Colorectal Surgery

NCT05331196 | Completed

• 1 other identifier: 2022_052
• Study Type: observational
• Target: 114
• Locations: 1 country
• Sites: 1

Brief Summary

A cardiopulmonary exercise test (CPET) is increasingly used for preoperative risk assessment. Oxygen uptake (VO2) at peak exercise (VO2peak) and VO2 at the ventilatory anaerobic threshold (VO2VAT) are the most commonly used preoperative CPET variables that are associated with postoperative outcomes following colorectal cancer surgery. The aim of this study is to investigate the association between preoperative submaximal and effort-independent CPET variables and postoperative outcomes in colorectal cancer surgery. Specifically, the slope of the relation between minute ventilation and carbon dioxide production (VE/VCO2-slope) and the oxygen uptake efficiency slope (OUES) will be investigated.

Conditions

Colorectal Cancer

Keywords

Cardiopulmonary exercise testing; prehabilitation; OUES

Outcome Measures

Primary Outcomes (1)

• Postoperative complications

  Postoperative complications scored using Clavien-Dindo clasification gade (1-5)

  30 days postoperative

Secondary Outcomes (2)

• Length of stay

  60 days

• Readmissions

  30 days postoperative

Study Arms (1)

Patients with colorectal cancer

Patients with colorectal cancer who underwent elective surgery.

Diagnostic Test: Preoperative cardiopulmonary exercise tetsing

Interventions

Preoperative cardiopulmonary exercise tetsing DIAGNOSTIC_TEST

Patients underwent a cardiopulmonary exercise test prior to surgery.

Patients with colorectal cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with colorectal cancer stage I-III who underwent elective surgery in in Medisch Spectrum Twente (MST) Maxima Medical Center (MMC), Maastricht University Medical Center (MUMC), VieCuri Medical Center (VMC) and underwent preoperative CPET.

You may qualify if:

• Patients who had a preoperative CPET and who underwent elective colorectal surgery and where, \> 18 years (MMC, VMC) or ≥60 years (MST), with a score ≤7 metabolic equivalents on the veterans-specific activity questionnaire (MST, MUMC+,VMC).

You may not qualify if:

• Patients who participated in exercise prehabilitation prior to surgery

Sponsors & Collaborators

• VieCuri Medical Centre: lead
• Maxima Medical Center: collaborator
• Medisch Spectrum Twente: collaborator
• Maastricht University Medical Center: collaborator

Study Sites (1)

Viecuri medical center

Venlo, Limburg, 5995BL, Netherlands

Location

Related Publications (1)

• Franssen RFW, Berkel AEM, Ten Cate DWG, van der Palen J, van Meeteren NLU, Vogelaar FJ, Slooter G, Klaase JM, Janssen-Heijnen MLG, Bongers BC. A retrospective analysis of the association of effort-independent cardiopulmonary exercise test variables with postoperative complications in patients who underwent elective colorectal surgery. Langenbecks Arch Surg. 2023 Dec 14;409(1):7. doi: 10.1007/s00423-023-03197-5.

  PMID: 38093118 DERIVED

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 8, 2022
• First Posted: April 15, 2022
• Study Start: April 15, 2022
• Primary Completion: July 15, 2022
• Study Completion: October 15, 2022
• Last Updated: November 23, 2022

Record last verified: 2022-08

Locations

NL (1)