NCT05321914

Brief Summary

The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:

  1. 1.Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity
  2. 2.Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength
  3. 3.Compare the acute glucose responses to resistance exercise performed in the morning vs the evening

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 1, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

April 11, 2022

Completed
20 days until next milestone

Study Start

First participant enrolled

May 1, 2022

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2024

Completed
Last Updated

March 30, 2025

Status Verified

March 1, 2025

Enrollment Period

1.8 years

First QC Date

April 1, 2022

Last Update Submit

March 25, 2025

Conditions

Metabolic Disease

Keywords

exercisemusclemetabolismcircadian

Outcome Measures

Primary Outcomes (1)

  • Change in insulin sensitivity

    Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test

    Change from baseline to 6 weeks

Secondary Outcomes (8)

  • Change in vastus lateralis muscle thickness

    Change from baseline to 6 weeks

  • Change in whole body lean mass

    Change from baseline to 6 weeks

  • Change in whole body fat mass

    Change from baseline to 6 weeks

  • Change in one-repetition maximum muscle strength

    Change from baseline to 6 weeks

  • Change in knee extensor maximal isometric torque

    Change from baseline to 6 weeks

  • +3 more secondary outcomes

Study Arms (3)

Control

NO INTERVENTION

Habitual physical activity

Morning exercise

EXPERIMENTAL

Exercise training in the morning (6:00-10:00am)

Behavioral: Exercise training

Evening exercise

EXPERIMENTAL

Exercise training in the evening (4:00-8:00pm)

Behavioral: Exercise training

Interventions

Exercise trainingBEHAVIORAL

Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Evening exerciseMorning exercise

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • pass the physical activity readiness questionnaire
  • body mass index (BMI) \>27kg/m² and limited to 40 kg/m².

You may not qualify if:

  • Prior surgery for weight loss
  • Prior history of heart, lung, cancer, endocrine or liver disease
  • Participating in more than 1 hour structured exercise training per week

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Stuart Robert Gray

Glasgow, United Kingdom

Location

Related Publications (1)

  • Dighriri A, Lithgow H, Gabriel B, Altuwrqi M, Dunning E, Johnston L, Boyle JG, Logan G, Gray SR. The impact of the time of day on muscle and metabolic responses to resistance exercise in healthy adults: A randomised controlled trial. Exp Physiol. 2025 Nov 13. doi: 10.1113/EP093020. Online ahead of print.

    PMID: 41231202DERIVED

MeSH Terms

Conditions

Metabolic DiseasesMotor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Nutritional and Metabolic DiseasesBehavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Lecturer

Study Record Dates

First Submitted

April 1, 2022

First Posted

April 11, 2022

Study Start

May 1, 2022

Primary Completion

February 1, 2024

Study Completion

February 1, 2024

Last Updated

March 30, 2025

Record last verified: 2025-03

Locations

GB(1)