NCT06188728

Brief Summary

A group of 120 school teachers (male=60, female=60) was divided into four subgroups for sixteen weeks of an interventional study. One group was kept in control while the other three groups were assigned intervention. One group was assigned intervention of lifestyle modification (LSM), the other group assigned the intervention of 5 gm psyllium husk fiber (PSH) two times a day, and the third group assigned the combined intervention of LSM \& PSH. Each group comprised of 30 subjects with equal gender bifurcation (15 male and 15 female).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 7, 2020

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 27, 2021

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 30, 2021

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

March 14, 2022

Completed
1.8 years until next milestone

First Posted

Study publicly available on registry

January 3, 2024

Completed
Last Updated

January 5, 2024

Status Verified

January 1, 2024

Enrollment Period

9 months

First QC Date

March 14, 2022

Last Update Submit

January 3, 2024

Conditions

Keywords

insulin resistance,High sensitive C reactive proteinLipid ProfileSleep quality analysisAbdomens and epigastric health

Outcome Measures

Primary Outcomes (7)

  • Anthropometry

    weight (Kg),

    16 weeks

  • Lipid Profile

    Triglyceride, LDL, HDL and cholesterol. unit used was mg/dl.

    16 weeks

  • Sleep quality analysis

    wil use Pittesburge Sleep Quality Index score (ranging from 0 to 6. where 0 reflect best sleep quality and 7 represent the worst sleep quality)

    16 weeks

  • abdomen and epigastric health

    Likert scale (0-7). 0 represents good health and 7 represent worst epigastric and abdominal health

    16 weeks

  • height (cm)

    Measure height in cm (centimeter)

    16 weeks

  • Waist circumference

    Measure waist circumference in cm (centimeter)

    16 weeks

  • BMI

    weight and height will be combine to calculate the BMI (kg/m\^2)

    16 weeks

Secondary Outcomes (2)

  • Insulin resistance

    16 weeks

  • high sensitive C reactive protein

    16 weeks

Study Arms (4)

Control group

PLACEBO COMPARATOR

Group-I comprised of 30 subjects, 15 male and 15 female. The group was assigned no intervention and kept as the control group.

Other: Control

LSM group

EXPERIMENTAL

Group II comprised 30 subjects with the equal bifurcation of male and female. Group II was assigned the intervention of lifestyle modification (the combination of diet, physical activity, and behavior therapy)

Behavioral: Effect of life style modification (Diet, Behavior and physical activity)

PSH group

EXPERIMENTAL

Group III comprised of 30 subjects, 15 male and 15 female. Group III was assigned the 5gm psyllium husk fiber (in swelled form) two times a day, i.e., 30 minutes before breakfast and 30 minutes before dinner. All the subjects in the physical demonstration were briefed about the preparation and usage of psyllium husk fiber.

Dietary Supplement: effect of 10 gm psyllium husk fiber twice a day, 30 minutes before breakfast and dinner

LSM&PSH

EXPERIMENTAL

Group IV comprised of 30 subjects, 15 male and 15 female. Group IV was assigned both the intervention of psyllium husk fiber @ 5gm two times a day, 30 minutes before breakfast and dinner in swelled gel form with the combination of lifestyle modification

Combination Product: Combined effect of 10 gm Psyllium husk fiber and lifestyle modification

Interventions

comparing the effect of psyllium husk fiber and lifestyle modification alone with the combined effect of psyllium husk fiber on metabolic health of centrally obese school teachers

PSH group

To assess the effect of life style modification (Diet, Behavior and physical activity) on centrally obese school teachers

LSM group

To evaluate the combined effect of 10 gm psyllium husk fiber in gel form, 30 minutes before breakfast and dinner along with dietary, behavioral and physical activity modification on centrally obese school teachers

LSM&PSH
ControlOTHER

No intervention

Control group

Eligibility Criteria

Age40 Years - 60 Years
Sexall(Gender-based eligibility)
Gender Eligibility Detailsan equal number of males and females were enrolled in the study with similar cultural, geographical and profession background
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • School teachers aged 40-60 years (male and female)
  • central obesity (where central obesity for Asians is defined as the waist circumference for men ≥ 90 cm and for women ≥ 80 cm
  • with no history of any chronic disease like hypertension, Diabetes, Cardiovascular diseases, taking of any regular medication, food allergies, smoking

You may not qualify if:

  • Pregnant or lactating female school teachers were also excluded during screening.
  • Subjects with an allergy to psyllium husk fiber, history of drug abuse, or any psychological or emotional disorder that might prevent the completion of the study were also excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Agriculture

Peshawar, Khyberpakhtunkhwa, 25000, Pakistan

Location

MeSH Terms

Conditions

Metabolic DiseasesInsulin Resistance

Interventions

MealsDietExercise

Condition Hierarchy (Ancestors)

Nutritional and Metabolic DiseasesHyperinsulinismGlucose Metabolism Disorders

Intervention Hierarchy (Ancestors)

FoodDiet, Food, and NutritionPhysiological PhenomenaFood and BeveragesNutritional Physiological PhenomenaMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Zia Din, PhD

    Chairman department of human Nutrition

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: comparing the intervention group with the control (intervention include either lifestyle modification, psyllium husk fiber or combined intervention of lifestyle modification and psyllium husk fiber.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr.

Study Record Dates

First Submitted

March 14, 2022

First Posted

January 3, 2024

Study Start

September 7, 2020

Primary Completion

May 27, 2021

Study Completion

July 30, 2021

Last Updated

January 5, 2024

Record last verified: 2024-01

Data Sharing

IPD Sharing
Will share

once the paper is approved and research data updated to HEC digital library

Shared Documents
CSR
Time Frame
once the research paper published
Access Criteria
through google scholar

Locations