POWER UP: Participating Online While Exercising to Recover Using Play

NCT05308407 | Terminated

• 2 other identifiers: 2021-0887NCI-2022-02423
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

We will conduct a two-phase study. The first phase is to adapt and develop an active video game (AVG)-centered lifestyle physical activity (PA) intervention (POWER UP) for adolescents and young adults (AYA) with central nervous system tumors. The second phase is to test the feasibility and preliminary efficacy of a 12-week virtually delivered, group-based active video game-centered lifestyle physical activity intervention on function and quality of life in AYAs (aged 15-39) who are ≤1-year post-surgery for a central nervous system tumor. This population is at very high-risk for steep functional decline.

Conditions

Exercise; Central Nervous System Tumors; Tumors

Outcome Measures

Primary Outcomes (1)

• Quality of Life Questionnaire

  PROMIS 29 includes the following domains * Physical Function (5=without any difficulty, 1=unable to do) * Anxiety (5=always, 1=never) * Depression (5=always, 1=never) * Fatigue (5=very much, 1=not at all) * Sleep Disturbance (5=very poor, 1=very good) * Ability to participate in Social Roles and Activities(5=never, 1=always) * Pain Interference (5=very much, 1=not at all) * Pain Intensity (10=worst pain imaginable, 0=no pain)

  through study completion, an average of 1 year

Study Arms (2)

Aim 1. Focus Groups

OTHER

Healthcare providers (n=16-24 participants in 4 focus groups) from MD Anderson Cancer Center (MDACC). AYAs with primary benign or malignant central nervous system tumors (n=16-24 participants in 4 focus groups) treated at MDACC.

Other: Focus Groups

Aim 2. Pilot randomized controlled trial:

OTHER

AYAs with primary benign or malignant central nervous system tumors (n=80 patients approached, with n= 40 participants consented and randomized to the intervention (n=20) or usual care control group (n=20)) treated at MDACC, any gender and race, who are ≤1-year post-surgery for a central nervous system tumor.

Other: Pilot randomized controlled trial

Interventions

Focus Groups OTHER

No intervention involved in this phase of the study

Aim 1. Focus Groups

Pilot randomized controlled trial OTHER

The intervention is a virtually delivered, 12 weekly group-based active video game-centered lifestyle physical activity intervention (POWER UP) targeting affect to improve function and quality of life in insufficiently active AYAs with central nervous system tumors.

Aim 2. Pilot randomized controlled trial:

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• In order to be eligible to participate in Aim 1 of this study, an individual must meet all of the following criteria:
• Round 1 focus groups:
• Oncologists who are caring for AYA cancer survivors or
• Survivorship care providers who actively engage with AYA cancer survivors
• Round 2 focus groups:
• AYA cancer survivors age 15-39 years old
• Self-reported diagnosis of a primary benign or malignant CNS tumor or confirmed diagnosis of primary benign or malignant CNS tumor radiographically or pathologically when available
• ≤1-year post surgery and can have other tumor-directed treatment (e.g., radiation and/or chemotherapy)
• Participants and/or guardians are willing and able to provide informed consent
• Able to speak, read, and understand English
• Daily access to the web
• Can receive physical therapy because this is part of the standard of care
• In order to be eligible to participate in Aim 2 of this study, an individual must meet all of the following criteria:
• Age 15-39 years old
• Self-reported diagnosis of a primary benign or malignant CNS tumor or confirmed diagnosis of primary benign or malignant CNS tumor radiographically or pathologically when available

You may not qualify if:

• An individual who meets any of the following criteria will be excluded from participation in Aim 1 of this study:
• Round 1 Focus Groups:
• \. Do not have access to the internet
• Round 2 Focus Groups:
• Another member of the household is a participant or staff member on this trial
• Do not have access to the internet
• In foster care or is incarcerated
• Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.
• Self-reported diagnosis of a metastatic CNS tumor or confirmed diagnosis of a metastatic CNS tumor radiographically or pathologically when available
• An individual who meets any of the following criteria will be excluded from participation in Aim 2 of this study:
• Currently pregnant
• Currently have dementia
• Plans to travel for more than 2 weeks at a time during the study period where the participant is not able to sign in to join the videoconferencing sessions
• Clinical judgment by the oncology care team concerning safety based on the Physical Activity Readiness Questionnaire for Everyone (2020 PAR-Q+)
• Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead

Study Sites (1)

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

• M D Anderson Cancer Center

MeSH Terms

Conditions

Motor Activity; Central Nervous System Neoplasms; Neoplasms

Interventions

Focus Groups

Condition Hierarchy (Ancestors)

Behavior; Nervous System Neoplasms; Neoplasms by Site; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Keri L Schadler, MD

  M.D. Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 15, 2022
• First Posted: April 4, 2022
• Study Start: May 4, 2022
• Primary Completion: July 29, 2025
• Study Completion: July 29, 2025
• Last Updated: August 5, 2025

Record last verified: 2025-07

Locations

US (1)