The Effects of High-Intensity Exercise on Biological Age

NCT05156918 | Completed

• 1 other identifier: 5210437
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this graduate student research study is to determine if a high-intensity exercise program can slow or reverse biological (transcriptomic) aging and shed light on the underlying transcriptomic pathways involved.

Conditions

Exercise

Outcome Measures

Primary Outcomes (1)

• venipuncture procedure

  Participants will have 8ml of blood drawn on two separate occasions by a certified phlebotomist. The first 8 ml (1.62tsp) blood draw will occur at 8am on day 1 of the study protocol. The second 8ml (1.62tsp) blood draw will occur approximately 30 days later. The total blood draw volume will be 16ml or approximately 3.25 teaspoons. The blood draw is to test for the effects of exercise on gene expression and aging.

  Change between baseline and 30 days

Secondary Outcomes (2)

• Perceived stress scale survey

  Change between baseline and 30 days

• Pittsburgh Sleep Quality Index

  Change between baseline and 30 days

Study Arms (2)

Exercise Group

EXPERIMENTAL

Exercise group participants will perform supervised high intensity exercise three times per week at the LLU department of physical therapy laboratory utilizing treadmills, stationary bicycles, and rowing machines.

Other: Exercise

Control Group

ACTIVE COMPARATOR

Control group participants will make no modifications to regular diet or exercise habits for 30 days.

Other: Non Exercise

Interventions

Exercise OTHER

Participants will rotate between three exercise machines (randomly assigned rotation order at outset): A Concept C2 rowing machine, a stationary bicycle, and a treadmill. Study participants will use a different machine each day so that they are using each of the three exercise machines once per week. Two treadmills, two bikes, and two rowers are available during each exercise session. Participants will be randomly assigned to one of three machine orders: treadmill-rower-bike, rower-bike-treadmill, or bike-treadmill-rower. We will employ a percent of heart rate protocol as an exercise intensity measure (77-93% of age-adjusted maximum heart rate) rather than a less well-defined maximal effort protocol or rating of perceived exertion scale. For the purposes of this exercise protocol high intensity exercise will be defined as 77-93% of age adjusted maximum heart rate.

Exercise Group

Non Exercise OTHER

There are no modifications to regular diet or exercise habits for 30 days.

Control Group

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sex: Both Males and Females
• Age: 40-65 years old
• Physical Fitness: Below average scores on the Self report fitness questionnaire
• Physical Activity: Low as measured by the International Physical Activity Questionnaire

You may not qualify if:

• Prior (within the last 5 years) or current history of cardiovascular disease, stroke, unexplained weight loss, clinical depression, congestive heart failure, cancer, arrythmia, respiratory disease, or other serious medical conditions that would make exercise unsafe or prevent full participation in the exercise protocol.
• Any self-reported significant increase or decrease in activity levels within the past thirty days.
• Current use of the following medications: antibiotics, glucocorticoids, anticoagulants, narcotics, antiepileptic medications, antipsychotics, antidepressants, and hypoglycemic agents.
• Current self-reported pregnancy

Sponsors & Collaborators

• Loma Linda University: lead

Study Sites (1)

Loma Linda University

Loma Linda, California, 92350, United States

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Gurinder Bains, PhD

  Loma Linda University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor School of Allied Health

Study Record Dates

• First Submitted: November 29, 2021
• First Posted: December 14, 2021
• Study Start: November 29, 2021
• Primary Completion: June 28, 2022
• Study Completion: June 28, 2022
• Last Updated: June 30, 2022

Record last verified: 2022-06

Locations

US (1)