AI to Improve Data From Danish Cardiac Arrest Registry

NCT05308303 | Unknown DMC

• 1 other identifier: AI_CA_2022
• Study Type: observational
• Target: 31,200
• Locations: 1 country
• Sites: 1

Brief Summary

Out-of-hospital cardiac arrest is a leading cause of death worldwide and patient outcome vary substantially throughout regions suggesting further evaluation and potential for improvement.When focussing on subgroups of OHCA, data in certain areas remains scarce and the need of revised guidelines is evident. Furthermore, enhanced knowledge on these varieties of OHCA's apply to substantial number of patients, also among vulnerable populations. The Danish Emergency Medical System introduced a nationwide registry of electronic medical reports in 2016. This report system allows electronic searches and thereby the opportunity to identify subgroups of OHCA's. Thus, this novel reporting enables the evaluation of new characteristics of cardiac arrests of non-cardiac origin, in cases where an automated external defibrillator (AED) is retrieved but did not recommend defibrillation and finally in OHCA related to foreign body obstruction. With the advantages of artificial intelligence, this project will enhance and strengthen data from the Danish Cardiac Arrest Registry. It may substitute the manual validation of the around 9000 cases per year in Denmark. Further, it proposes improvement of quality and development of observational health research.

Conditions

Out-Of-Hospital Cardiac Arrest; Trauma; Drug Overdose; Electrocution; Asphyxia; Airway Obstruction

Keywords

Out-of-Hospital Cardiac Arrest of non-cardiac origin; traumatic Cardiac Arrest; Drug Overdose; Electrocution; Asphyxia; Cardiopulmonary Resuscitation; Emergency Medical Service

Outcome Measures

Primary Outcomes (2)

• Survival

  Status at admission. Categorical variable, polytomous outcome. (declared dead on scene, ongoing cpr, ROSC but unconscious, ROSC and aware)

  The timeframe is at the time of hospital admission, therefore no specific time point (ie 24-hours, 1hour ect) can be stated

• longterm survival

  30-day survival

  30 day

Secondary Outcomes (1)

• ROSC at any time

  The timeframe is from incident (at scene) to admission to hospital. As of such it is not meassured at any specific time or time point, however the timeframe does not exceed 6 hours

Study Arms (2)

All cause OHCA

OHCA of non-cardiac origin

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study evaluates OHCA from non-cardiac origin in the general population of Denmark between 2016 to 2021

You may qualify if:

• OHCA from non-cardiac origin (trauma, asphyxia, electrocution, drowning, overdose)

You may not qualify if:

• OHCA from cardiac origin

Sponsors & Collaborators

• Prehospital Center, Region Zealand: lead

Study Sites (1)

Prehospital Center

Næstved, Denmark

Location

Related Publications (7)

• Cummins RO, Chamberlain DA, Abramson NS, Allen M, Baskett PJ, Becker L, Bossaert L, Delooz HH, Dick WF, Eisenberg MS, et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style. A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation. 1991 Aug;84(2):960-75. doi: 10.1161/01.cir.84.2.960. No abstract available.

  PMID: 1860248 BACKGROUND

• Lindskou TA, Mikkelsen S, Christensen EF, Hansen PA, Jorgensen G, Hendriksen OM, Kirkegaard H, Berlac PA, Sovso MB. The Danish prehospital emergency healthcare system and research possibilities. Scand J Trauma Resusc Emerg Med. 2019 Nov 4;27(1):100. doi: 10.1186/s13049-019-0676-5.

  PMID: 31684982 BACKGROUND

• Claesson A, Djarv T, Nordberg P, Ringh M, Hollenberg J, Axelsson C, Ravn-Fischer A, Stromsoe A. Medical versus non medical etiology in out-of-hospital cardiac arrest-Changes in outcome in relation to the revised Utstein template. Resuscitation. 2017 Jan;110:48-55. doi: 10.1016/j.resuscitation.2016.10.019. Epub 2016 Nov 5.

  PMID: 27826118 BACKGROUND

• Christensen DM, Rajan S, Kragholm K, Sondergaard KB, Hansen OM, Gerds TA, Torp-Pedersen C, Gislason GH, Lippert FK, Barcella CA. Bystander cardiopulmonary resuscitation and survival in patients with out-of-hospital cardiac arrest of non-cardiac origin. Resuscitation. 2019 Jul;140:98-105. doi: 10.1016/j.resuscitation.2019.05.014. Epub 2019 May 23.

  PMID: 31129226 BACKGROUND

• Lott C, Truhlar A, Alfonzo A, Barelli A, Gonzalez-Salvado V, Hinkelbein J, Nolan JP, Paal P, Perkins GD, Thies KC, Yeung J, Zideman DA, Soar J; ERC Special Circumstances Writing Group Collaborators. European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation. 2021 Apr;161:152-219. doi: 10.1016/j.resuscitation.2021.02.011. Epub 2021 Mar 24.

  PMID: 33773826 BACKGROUND

• Kleber C, Giesecke MT, Lindner T, Haas NP, Buschmann CT. Requirement for a structured algorithm in cardiac arrest following major trauma: epidemiology, management errors, and preventability of traumatic deaths in Berlin. Resuscitation. 2014 Mar;85(3):405-10. doi: 10.1016/j.resuscitation.2013.11.009. Epub 2013 Nov 25.

  PMID: 24287328 BACKGROUND

• Hess EP, Campbell RL, White RD. Epidemiology, trends, and outcome of out-of-hospital cardiac arrest of non-cardiac origin. Resuscitation. 2007 Feb;72(2):200-6. doi: 10.1016/j.resuscitation.2006.06.040. Epub 2006 Nov 22.

  PMID: 17118509 BACKGROUND

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest; Wounds and Injuries; Drug Overdose; Asphyxia; Airway Obstruction

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases; Prescription Drug Misuse; Drug Misuse; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Insufficiency; Respiration Disorders; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, principal investigator

Study Record Dates

• First Submitted: February 24, 2022
• First Posted: April 4, 2022
• Study Start: June 1, 2022
• Primary Completion: June 1, 2023
• Study Completion: June 1, 2023
• Last Updated: September 29, 2022

Record last verified: 2022-09

Locations

DK (1)