NCT05142124

Brief Summary

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
400

participants targeted

Target at P75+ for all trials

Timeline
14mo left

Started Jul 2021

Longer than P75 for all trials

Geographic Reach
1 country

25 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress81%
Jul 2021Jun 2027

Study Start

First participant enrolled

July 21, 2021

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

November 8, 2021

Completed
24 days until next milestone

First Posted

Study publicly available on registry

December 2, 2021

Completed
5.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2027

Last Updated

February 12, 2026

Status Verified

February 1, 2026

Enrollment Period

5.4 years

First QC Date

November 8, 2021

Last Update Submit

February 10, 2026

Conditions

Out-of-hospital Cardiac Arrest

Keywords

Out-of-hospital Cardiac ArrestOHCAresuscitationcardiac arrest centeracute care medicineintensive carepost-resuscitation care

Outcome Measures

Primary Outcomes (1)

  • In hospital mortality

    until discharge, an average of 2 weeks

Secondary Outcomes (15)

  • Length of ICU stay

    until discharge, an average of 2 weeks

  • Length of hospital stay

    until discharge, an average of 2 weeks

  • Mortality

    Day 30

  • Mortality

    Month 6

  • European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)

    Month 6

  • +10 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

patients with out-of-hospital cardiac arrest with assumed cardiovacular cause

You may qualify if:

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

You may not qualify if:

  • rejection of register participation by patient or legal representative

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (25)

CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum

Berlin, State of Berlin, 13353, Germany

ACTIVE NOT RECRUITING

SLK-Kliniken Heilbronn - Klinikum am Plattenwald

Bad Friedrichshall, 74177, Germany

RECRUITING

Charité Universitätsmedizin Berlin - Deutsches Herzzentrum Berlin

Berlin, 12203, Germany

RECRUITING

Universitätsklinikum Bonn

Bonn, Germany

RECRUITING

Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser

Bremen, 28277, Germany

RECRUITING

Herzzentrum der Universität zu Köln

Cologne, 50937, Germany

RECRUITING

Herzzentrum Dresden GmbH

Dresden, 01307, Germany

ACTIVE NOT RECRUITING

Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie

Düsseldorf, 40225, Germany

RECRUITING

Elisabeth Krankenhaus Essen - Klinik für Akut- und Notfallmedizin

Essen, 45138, Germany

RECRUITING

Klinikum Frankfurt Höchst

Frankfurt, 65929, Germany

RECRUITING

Universitätsklinikum Halle (Saale)

Halle, 06120, Germany

RECRUITING

Universitäres Herz- und Gefäßzentrum Hamburg

Hamburg, 20246, Germany

RECRUITING

Asklepios Klinik St- Georg Hamburg

Hamburg, Germany

RECRUITING

SLK-Kliniken Heilbronn - Klinikum am Gesundbrunnen

Heilbronn, 74078, Germany

RECRUITING

Universitätsklinikum des Saarlandes

Homburg, Germany

RECRUITING

Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology

Leipzig, 04289, Germany

RECRUITING

Klinikum der Stadt Ludwigshafen gGmbH

Ludwigshafen, 67063, Germany

RECRUITING

Herzzentrum Lübeck

Lübeck, Germany

RECRUITING

Universitätsklinikum Mannheim

Mannheim, 68167, Germany

RECRUITING

Klinikum der Universität München

München, 81377, Germany

RECRUITING

Marienhaus Klinikum Hetzelstift

Neustadt, 67434, Germany

RECRUITING

Hegau-Bodensee Klinikum

Singen, 78224, Germany

RECRUITING

Hegau-Bodensee-Klinikum Singen

Singen, 78224, Germany

NOT YET RECRUITING

Schwarzwald-Baar Klinikum VS

Villingen-Schwenningen, 78052, Germany

RECRUITING

Dr. Horst Schmidt Kliniken

Wiesbaden, Germany

ACTIVE NOT RECRUITING

Related Publications (2)

  • Poss J, Sinning C, Rossberg M, Hosler N, Ouarrak T, Bottiger BW, Ewen S, Wienbergen H, Voss F, Dutzmann J, Tigges E, Voigt I, Freund A, Desch S, Michels G, Thiele H, Zeymer U; G-CAR Investigators. German Cardiac Arrest Registry (G-CAR)-results of the pilot phase. Clin Res Cardiol. 2025 Oct;114(10):1270-1279. doi: 10.1007/s00392-024-02468-5. Epub 2024 Jun 13.

    PMID: 38869632DERIVED

  • Poss J, Sinning C, Schreiner I, Apfelbacher C, Drewitz KP, Hosler N, Schneider S, Pieske B, Bottiger BW, Ewen S, Wienbergen H, Kelm M, Bock D, Graf T, Adler C, Dutzmann J, Knie W, Orban M, Zeymer U, Michels G, Thiele H; G-CAR Investigators. German Cardiac Arrest Registry: rationale and design of G-CAR. Clin Res Cardiol. 2023 Apr;112(4):455-463. doi: 10.1007/s00392-022-02044-9. Epub 2022 Jun 21.

    PMID: 35729429DERIVED

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart ArrestHeart DiseasesCardiovascular Diseases

Study Officials

  • Janine Pöss, Dr.

    Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology

    STUDY CHAIR

Central Study Contacts

Janine Pöss, Dr.

CONTACT

+49 341 865janine.poess@medizin.uni-leipzig.de

Holger Thiele, Prof.

CONTACT

+49 341 865holger.thiele@medizin.uni-leipzig.de

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
12 Months
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 8, 2021

First Posted

December 2, 2021

Study Start

July 21, 2021

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

June 30, 2027

Last Updated

February 12, 2026

Record last verified: 2026-02

Locations

DE(25)