NCT05305170

Brief Summary

Our translational project aims to evaluate the role of eicosanoids in human HF.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Aug 2021

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2021

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

March 22, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 31, 2022

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2023

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
Last Updated

April 8, 2022

Status Verified

March 1, 2022

Enrollment Period

2.4 years

First QC Date

March 22, 2022

Last Update Submit

March 31, 2022

Conditions

Heart Failure

Keywords

heart failureeicosanoidsreverse remodeling

Outcome Measures

Primary Outcomes (1)

  • Plasmatic levels of eicosanoids

    EET, DHET, 20-HETE

    at enrollment

Secondary Outcomes (1)

  • Mortality

    2 years

Study Arms (2)

HF

Patients with heart failure.

Diagnostic Test: Levels of EETs, DHETs and HETEs

Controls

Controls without heart failure.

Diagnostic Test: Levels of EETs, DHETs and HETEs

Interventions

Levels of EETs, DHETs and HETEsDIAGNOSTIC_TEST

The plasmatic concentration of EETs, DHETs, and HETEs.

ControlsHF

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Heart failure patients from our tertiary cardiovascular center and controls from the central hospital laboratory.

You may qualify if:

  • Heart failure

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Motol

Prague, Czechia

RECRUITING

Related Publications (12)

  • Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, Allison M, Hemingway H, Cleland JG, McMurray JJV, Rahimi K. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018 Feb 10;391(10120):572-580. doi: 10.1016/S0140-6736(17)32520-5. Epub 2017 Nov 21.

    PMID: 29174292BACKGROUND

  • McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A; ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368. No abstract available.

    PMID: 34447992BACKGROUND

  • Vaduganathan M, Claggett BL, Jhund PS, Cunningham JW, Pedro Ferreira J, Zannad F, Packer M, Fonarow GC, McMurray JJV, Solomon SD. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Lancet. 2020 Jul 11;396(10244):121-128. doi: 10.1016/S0140-6736(20)30748-0. Epub 2020 May 21.

    PMID: 32446323BACKGROUND

  • Imig JD, Cervenka L, Neckar J. Epoxylipids and soluble epoxide hydrolase in heart diseases. Biochem Pharmacol. 2022 Jan;195:114866. doi: 10.1016/j.bcp.2021.114866. Epub 2021 Dec 2.

    PMID: 34863976BACKGROUND

  • Fan F, Roman RJ. Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology. J Am Soc Nephrol. 2017 Oct;28(10):2845-2855. doi: 10.1681/ASN.2017030252. Epub 2017 Jul 12.

    PMID: 28701518BACKGROUND

  • Jamieson KL, Endo T, Darwesh AM, Samokhvalov V, Seubert JM. Cytochrome P450-derived eicosanoids and heart function. Pharmacol Ther. 2017 Nov;179:47-83. doi: 10.1016/j.pharmthera.2017.05.005. Epub 2017 May 25.

    PMID: 28551025BACKGROUND

  • Elmarakby AA. Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 1;302(3):R321-30. doi: 10.1152/ajpregu.00606.2011. Epub 2011 Nov 23.

    PMID: 22116511BACKGROUND

  • Sporkova A, Reddy RN, Falck JR, Imig JD, Kopkan L, Sadowski J, Cervenka L. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. Am J Med Sci. 2016 May;351(5):513-9. doi: 10.1016/j.amjms.2016.02.030. Epub 2016 Feb 23.

    PMID: 27140711BACKGROUND

  • Fleming I. The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease. Pharmacol Rev. 2014 Oct;66(4):1106-40. doi: 10.1124/pr.113.007781.

    PMID: 25244930BACKGROUND

  • Imig JD, Elmarakby A, Nithipatikom K, Wei S, Capdevila JH, Tuniki VR, Sangras B, Anjaiah S, Manthati VL, Sudarshan Reddy D, Falck JR. Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions. Front Physiol. 2010 Dec 3;1:157. doi: 10.3389/fphys.2010.00157. eCollection 2010.

    PMID: 21423396BACKGROUND

  • Gawrys O, Huskova Z, Baranowska I, Walkowska A, Sadowski J, Kikerlova S, Vanourkova Z, Honetschlagerova Z, Skaroupkova P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. J Hypertens. 2020 Sep;38(9):1802-1810. doi: 10.1097/HJH.0000000000002462.

    PMID: 32384390BACKGROUND

  • Kala P, Miklovic M, Jichova S, Skaroupkova P, Vanourkova Z, Maxova H, Gawrys O, Kompanowska-Jezierska E, Sadowski J, Imig JD, Falck JR, Veselka J, Cervenka L, Aiglova R, Vicha M, Gloger V, Taborsky M. Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation. Biomedicines. 2021 Aug 20;9(8):1053. doi: 10.3390/biomedicines9081053.

    PMID: 34440257BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Petr Kala, MD

Study Record Dates

First Submitted

March 22, 2022

First Posted

March 31, 2022

Study Start

August 1, 2021

Primary Completion

December 31, 2023

Study Completion

December 31, 2024

Last Updated

April 8, 2022

Record last verified: 2022-03

Locations

CZ(1)