Carbon Dioxide (CO2) and Cognitive Impairment

NCT05292378 | Completed Results

• 1 other identifier: Pro2021001570
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.

Conditions

Healthy

Keywords

Carbon Dioxide; Cognitive Impairment

Outcome Measures

Primary Outcomes (3)

• Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Basal Oxygen Consumption (OCR)

  Using blood samples collected 4 hours post-exposure, PMN activation was assessed by measurement of oxidative burst (oxygen consumption rate).

  4 hours after each exposure

• Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Total Stimulated Oxygen Consumption.

  Using blood samples collected 4 hours post-exposure, PMN activation was assessed by measurement of total stimulated oxygen consumption.

  4 hours after each exposure

• Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Time to Peak (TTP) Oxygen Consumption

  Using blood samples collected 4 hours post-exposure, PMN activation was assessed by measurement of time to peak (TTP) oxygen consumption.

  4 hours after each exposure

Study Arms (2)

High CO2 Exposure first, then low CO2 exposure second.

EXPERIMENTAL

At the first study visit the subject is exposed to 2500 ppm CO2 for 2.5 hours and at the second study visit the subject is exposed to 600 ppm CO2 for 2.5 hours.

Other: 2500 ppm Carbon Dioxide; Other: 600 ppm Carbon Dioxide

Low CO2 Exposure first, then high CO2 exposure second.

SHAM COMPARATOR

At the first study visit the subject is exposed to 600 ppm CO2 for 2.5 hours and at the second study visit the subject is exposed to 2500 ppm CO2 for 2.5 hours.

Other: 2500 ppm Carbon Dioxide; Other: 600 ppm Carbon Dioxide

Interventions

2500 ppm Carbon Dioxide OTHER

2.5 hour exposure to 2500 ppm carbon dioxide

High CO2 Exposure first, then low CO2 exposure second.; Low CO2 Exposure first, then high CO2 exposure second.

600 ppm Carbon Dioxide OTHER

2.5 hour exposure to 600 ppm carbon dioxide

High CO2 Exposure first, then low CO2 exposure second.; Low CO2 Exposure first, then high CO2 exposure second.

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• History of COVID-19 vaccination
• Weigh at least 110 pounds

You may not qualify if:

• Colorblindness
• Inability to hear verbal instructions
• Cardiovascular disease, including a history of stroke
• Diabetes requiring the use of insulin
• Pregnancy
• Current asthma (an asthma attack within the past five years)
• Medications for or history of anxiety disorder diagnosis or panic attacks
• Medications which may affect cognition such as beta-blockers and CNS depressants
• Respiratory symptoms in the previous four weeks
• Use of sedating cold/allergy medications in the previous week
• Use of marijuana in the previous week
• Consumption of alcohol in the previous 24 hours
• History of head trauma or neurosurgery or neurological disorder
• Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
• Surgical pins or plates above the neck

Sponsors & Collaborators

• Rutgers, The State University of New Jersey: lead

Study Sites (1)

Rutgers - EOHSI

Piscataway, New Jersey, 08854, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Results Point of Contact

• Title: Howard Kipen
• Organization: Rutgers the State University of New Jersey

kipen@eohsi.rutgers.edu

848-445-6082

Study Officials

• Howard Kipen, MD

  Professor

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 24, 2022
• First Posted: March 23, 2022
• Study Start: July 14, 2022
• Primary Completion: March 20, 2025
• Study Completion: March 20, 2025
• Last Updated: March 16, 2026
• Results First Posted: March 16, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)