NCT05286125

Brief Summary

Comparing the impact of bilateral erector spinae plane block and transverse abdominis plane block on improving quality of pain management after umbilical hernia repair.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
52

participants targeted

Target at below P25 for not_applicable postoperative-pain

Timeline
Completed

Started Jan 2021

Longer than P75 for not_applicable postoperative-pain

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 15, 2021

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

December 22, 2021

Completed
3 months until next milestone

First Posted

Study publicly available on registry

March 18, 2022

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 15, 2023

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2023

Completed
Last Updated

July 12, 2023

Status Verified

July 1, 2023

Enrollment Period

2.8 years

First QC Date

December 22, 2021

Last Update Submit

July 11, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Postoperative analgesic requirements

    measuring the total doses of analgesic required to relieve the pain

    24 hours postoperative

Secondary Outcomes (7)

  • Postoperative pain severity using Visual Analogue scale

    24 hours postoperative

  • Postoperative pain severity using Verbal Rating Scale

    24 hours postoperative

  • Postoperative pain severity using Numeric Rating Scale

    24 hours postoperative

  • Postoperative heart rate changes

    24 hours postoperative

  • Postoperative blood pressure changes

    24 hours postoperative

  • +2 more secondary outcomes

Study Arms (2)

erector spinae plane (ESP) block group ( (E) group)

ACTIVE COMPARATOR

Under aseptic conditions, a high frequency linear transducer will be placed on the spinous process at T8 level on the parasagittal plane and then slid 2.5-3 cm laterally to visualize the transverse process and erector spinae muscle.

Procedure: erector spinae plane (ESP) block

oblique subcostal transverse abdominis plane (TAP) block ( (T) group) )

ACTIVE COMPARATOR

Under aseptic conditions, the probe will be initially placed below the xyphoid process to view the linea alba, then directed obliquely down the costal margin while keeping the rectus abdominis muscle in view. The transverse abdominis muscle come into view below the rectus abdominis muscle. The probe will be advanced further until the semilunaris is viewed.

Procedure: oblique subcostal transverse abdominis plane (TAP) block

Interventions

Using the in plane technique, the needle will be advanced between the transverse process and erector spinae muscle. The correct location will be confirmed using 1ml of Local Anesthetic (LA) to view hydrodissection(12). 19ml of LA will be injected between the muscle and transverse process.

erector spinae plane (ESP) block group ( (E) group)

An echogenic needle will be inserted in-plane until the needle tip reaches the fascia between the rectus abdominis and the transverse abdominis muscles. Once the needle enters the TAP plane, a dynamic injection can be performed by advancing the needle under ultrasound guidance laterally in the pocket created by the initial injection of 5 - 10 mL of local anesthetic; as the needle is advanced, the remaining local anesthetic will be injected. This allows for a more lateral spread of the local anesthetic

oblique subcostal transverse abdominis plane (TAP) block ( (T) group) )

Eligibility Criteria

Age21 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Patients scheduled for elective umbilical hernia repair.
  • Patient acceptance.
  • Both sex
  • Patient's age 21 - 60 years.
  • Patients with American Society of Anesthesiologists (ASA) physical status I, II.
  • BMI 25 - 30 kg m-2.

You may not qualify if:

  • Uncooperative patients and patients with psychological problems.
  • Patients with liver or renal impairment.
  • Patients with contraindication to regional anesthesia.
  • Patients with history of allergy to drug used in the study.
  • Patients with chronic pain.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Zagazig University hospital

Zagazig, Sharqia Province, 44511, Egypt

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Interventions

ParapsychologyDental Occlusion

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

Behavioral SciencesBehavioral Disciplines and ActivitiesDentistryDental Physiological PhenomenaDigestive System and Oral Physiological Phenomena

Study Officials

  • Michael A shaker, lecturer

    Zagazig University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

michael A shaker, lecturer

CONTACT

salwa s ElSherbeny, lecturer

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
lecturer of anaesthesia and intensive care

Study Record Dates

First Submitted

December 22, 2021

First Posted

March 18, 2022

Study Start

January 15, 2021

Primary Completion

November 15, 2023

Study Completion

December 15, 2023

Last Updated

July 12, 2023

Record last verified: 2023-07

Locations