Individual Differences in Cognitive Control Predict Real-time fMRI Neurofeedback Performance

NCT07211269 | Recruiting

• 1 other identifier: UESTC-neuSCAN-95
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to investgate whether individual differences of cognitive control capacity could predict neurofeedback performance and the behavioral effects resulting from successful anterior insula regulation via interoceptive strategy.

Conditions

Healthy

Keywords

Neurofeedback Performance; Interoception; Cognitive Control

Outcome Measures

Primary Outcomes (2)

• BOLD signal of the anterior insula during neurofeedback training

  The anterior insula activity induced by regulation relative to rest blocks in the neurofeedback training task and transfer task.

  1 hour

• Behavioral measurements in the cognitive control tasks

  Response time and accuracy are recorded in the cognitive control tasks (i.e., the Go/No-Go task, Stroop task, Task-switching, N-back task).

  1 hour

Secondary Outcomes (4)

• Pain empathy ratings scores

  1 hour

• Strategy efficacy rating scores

  1 hour

• Intero-ceptive accuracy

  15 minutes

• Confidence rating scores of interoceptive sensitivity

  15 minutes

Study Arms (1)

Neurofeedback group

EXPERIMENTAL

Participants received real-time neurofeedback information from the target regulation brain region.

Other: Real-time fMRI neurofeedback training

Interventions

Real-time fMRI neurofeedback training OTHER

Real-time neurofeedback information is computed using the Turbo Brain voyager (TBV) 4.0 software (Brain Innovation, Maastricht, The Netherlands). Functional images are collected and processed in real time based on contrasts of regulation vs. rest conditions. The BOLD signal of the target region is then transformed into visual bars and displayed to participants via the projector screen while participants keep using regulation strategy (heartbeat interoception in our study) to upregulate the target region.

Neurofeedback group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects without any past or present psychiatric or neurological disorders

You may not qualify if:

• History of brain injury Medical or mental illness and color blindness or weakness.
• The presence of metal in the body or claustrophobia.

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

University of Electronic Science and Technology of China

Chengdu, Chengdu, 611731, China

RECRUITING

Study Officials

• Yao Shuxia, Dr.

  University of Electronic Science and Technology of China

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Keith M Kendrick, Dr.

CONTACT

86-28-61830811; k.kendrick.uestc@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: August 28, 2025
• First Posted: October 7, 2025
• Study Start: September 3, 2025
• Primary Completion: December 27, 2025
• Study Completion: January 12, 2026
• Last Updated: October 7, 2025

Record last verified: 2025-09

Locations

CN (1)