Study Stopped
Patients not recruited.
Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient
1 other identifier
interventional
N/A
1 country
1
Brief Summary
Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Feb 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2022
CompletedFirst Submitted
Initial submission to the registry
February 9, 2022
CompletedFirst Posted
Study publicly available on registry
February 24, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2023
CompletedMarch 7, 2023
March 1, 2023
1.1 years
February 9, 2022
March 5, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Strength of connectivity in brain network obtained from MRI neuroimaging data
Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.
Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks
Study Arms (1)
Intensive cognitive rehabilitation group
EXPERIMENTALParticipants receive intensive cognitive rehabilitation for 20 hours for 4 weeks.
Interventions
Intensive cognitive rehabilitation by cognitive therapist for 1 hour on every working 20 days (4 weeks) during the subacute stroke phase
Eligibility Criteria
You may qualify if:
- Patients aged 19 to 80 years
- Patients with subacute stroke within 2 weeks of onset
- First-ever stroke
- Supratentorial stroke
- Less than 8 SAFE (shoulder abduction, finger extension) points
- Less than 35 FMA Upper scores
- MEP (motor evoked potential) negative
- Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score
You may not qualify if:
- Difficult to communicate due to severe language impairment.
- Accompanied by an existing serious neurogenic disease
- Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
- If there are difficulties in conducting the research
- Any patients who are judged by the investigator to be difficult to participate in this study
- Patients with contraindicated MRI scans
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Samsung Medical Center
Seoul, 06351, South Korea
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
February 9, 2022
First Posted
February 24, 2022
Study Start
February 1, 2022
Primary Completion
February 28, 2023
Study Completion
February 28, 2023
Last Updated
March 7, 2023
Record last verified: 2023-03