The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received Non-surgical Periodontal Treatment.
Sponsor study identifier
interventional
15
1 country
1
Study Start
January 1, 2017
Actual (reported)Primary Completion
September 30, 2017
Actual (reported)Study Completion
August 30, 2018
Actual (reported)The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 30, 2018
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2017
Actual (reported)September 30, 2017
Actual (reported)August 30, 2018
Actual (reported)January 13, 2022
Actual (reported)February 10, 2022
Actual (reported)the change in GCF tissue plasminogen activator
Gingival crevicular fluid (GCF) samples were collected before SRP treatment and on days 7, 14 and 30 of follow- up and the change of the related mediator at those time points. The Amount of the related mediator were evaluated using enzyme- linked immunosorbent assay \[ELISA\] kit. Total amounts (pg/30 s) of the mediator collected from each sample in a 30- second period were calculated and recorded for analysis.
baseline and during follow-up visits on Days 7, 14 and 30.
the change in GCF plasminogen activator inhibitor 1
Gingival crevicular fluid (GCF) samples were collected before SRP treatment and on days 7, 14 and 30 of follow- up and the change of the related mediator at those time points. The Amount of the related mediator were evaluated using enzyme- linked immunosorbent assay \[ELISA\] kit. Total amounts (pg/30 s) of the mediator collected from each sample in a 30- second period were calculated and recorded for analysis.
baseline and during follow-up visits on Days 7, 14 and 30.
adjunctive application of low level laser therapy to non-surgical periodontal treatment
standart periodontal therapy
Beykent University
Istanbul, Turkey (Türkiye)
Pamuk F, Lutfioglu M, Paksoy T, Koyuncuoglu CZ, Polat NG, Cifcibasi E, Yildirim S, Kantarci A. Impact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3-4, Grade C periodontitis patients: a split-mouth, randomized control study. Clin Oral Investig. 2023 Nov;27(11):6439-6449. doi: 10.1007/s00784-023-05248-z. Epub 2023 Sep 15.
Ferda Pamuk Özer
Beykent University
15 participants (actual enrollment reported by the registry).
First Submitted
January 13, 2022
First Posted
February 10, 2022
Study Start
January 1, 2017
Actual (reported)Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
September 30, 2017
Actual (reported)Study Completion
August 30, 2018
Actual (reported)Last Updated
February 10, 2022
Record last verified: 2022-01
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Source: ClinicalTrials.gov.
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