The Effect of Periodontal Treatment on Psoriasis

NCT03939936 | Completed

• 1 other identifier: 17-KAEK-44
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

Conditions

Periodontal Diseases

Keywords

Psoriasis

Outcome Measures

Primary Outcomes (1)

• Proinflammatory cytokines

  The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.

  Baseline and after 8 weeks

Secondary Outcomes (2)

• Gingival index

  Baseline and after 8 weeks

• PASI index

  Baseline and after 8 weeks

Study Arms (2)

Test Group

ACTIVE COMPARATOR

Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Other: Psoriatic measurements; Other: Non-surgical periodontal treatment; Other: saliva samples

Control Group

PLACEBO COMPARATOR

Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment. Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Other: Psoriatic measurements; Other: saliva samples

Interventions

Psoriatic measurements OTHER

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Control Group; Test Group

Non-surgical periodontal treatment OTHER

Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Test Group

saliva samples OTHER

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Control Group; Test Group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• the presence at least 20 remaining teeth,
• the presence of Stage I or Stage II Periodontitis,
• the presence of diagnosed psoriasis.

You may not qualify if:

• patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
• patients who received periodontal treatment prior to 6 months,
• women who were breastfeeding or pregnant,
• patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Sponsors & Collaborators

• Ozge Gokturk: lead

Study Sites (1)

Gaziosmanpasa University

Tokat Province, 60250, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontal Diseases; Psoriasis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Atiye Ogrum

  Gaziosmanpasa Universty

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 26, 2019
• First Posted: May 7, 2019
• Study Start: May 1, 2017
• Primary Completion: January 30, 2018
• Study Completion: February 15, 2018
• Last Updated: May 9, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)