Real-time MRI for Evaluating Cardiac Volumetry
Comparison of Standard Breath-hold Cardiac MRI With a Faster, Free-breathing Scan
2 other identifiers
observational
570
1 country
1
Brief Summary
This study will compare the accuracy of a real-time Cine sequence in assessing cardiac volumetry.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2021
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 23, 2021
CompletedFirst Submitted
Initial submission to the registry
November 15, 2021
CompletedFirst Posted
Study publicly available on registry
February 3, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2025
CompletedNovember 29, 2023
November 1, 2023
3.9 years
November 15, 2021
November 24, 2023
Conditions
Outcome Measures
Primary Outcomes (7)
Cardiac volumetric assessment 1
Left ventricular ejection fraction
1 day
Cardiac volumetric assessment 2
Left ventricular end-diastolic volume
1 day
Cardiac volumetric assessment 3
Left ventricular myocardial mass
1 day
Cardiac volumetric assessment 4
Right ventricular ejection fraction
1 day
Cardiac volumetric assessment 5
Right ventricular end-diastolic volume
1 day
Cardiac strain assessment 1
Left ventricular global longitudinal strain
1 day
Cardiac strain assessment 2
Left ventricular global circumferential strain
1 day
Secondary Outcomes (3)
Time
1 day
Image quality assessment
1 day
Body-surface area
1 day
Interventions
CMR scan at 3 Tesla
Eligibility Criteria
Adults patients referred for routine cardiac MRI at Glenfield Hospital.
You may qualify if:
- Patients aged ≥ 18 years
- Referred for routine CMR imaging
- Willing and able to give informed consent
- Willing and able to comply with the requirements of the study
- Able to understand written English
You may not qualify if:
- Severe claustrophobia
- Unable to provide informed consent
- Participants unable to understand written English
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Glenfield Hospital
Leicester, Leics, LE3 9QP, United Kingdom
Related Publications (1)
Elshibly M, Shergill S, Parke K, Budgeon C, England R, Grafton-Clarke C, Elshibly F, Kellman P, McCann GP, Arnold JR. Standard breath-hold versus free-breathing real-time cine cardiac MRI-a prospective randomized comparison in patients with known or suspected cardiac disease. Eur Heart J Imaging Methods Pract. 2025 Apr 25;3(1):qyaf042. doi: 10.1093/ehjimp/qyaf042. eCollection 2025 Jan.
PMID: 40308862DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Jayanth Arnold
University of Leicester
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 15, 2021
First Posted
February 3, 2022
Study Start
February 23, 2021
Primary Completion
February 1, 2025
Study Completion
February 1, 2025
Last Updated
November 29, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share
no plan to share data