DeBakey Cardiovascular Magnetic Resonance Study

NCT04281823 | Recruiting

• 1 other identifier: Pro00008766
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

While advancements in cardiac magnetic resonance (CMR) have improved image quality, it is unclear how these improvements are connected to the clinical evaluation of individuals with cardiovascular disease. The aim of this large prospective registry revolves around 4 key principles: 1) utilize CMR to gain additional pathophysiologic insights into cardiovascular disease, 2) understand how CMR compares to alternative cardiovascular diagnostic modalities, 3) determine how CMR affects clinical management decisions, and 4) establish a link between CMR findings and long term prognosis in patients with known or suspected cardiovascular disease. The ultimate aim is to utilize CMR to improve patient outcomes. CMR techniques to be studies include function, fibrosis, and flow. Focus areas include valvular heart disease, ischemic heart disease, cardiomyopathies, and vascular disease.

Conditions

Cardiovascular Diseases

Keywords

Cardiovascular Disease; Cardiac Magnetic Resonance; Myocardial Fibrosis; Valvular Heart Disease; Ischemic Heart Disease; Cardiomyopathy

Outcome Measures

Primary Outcomes (4)

• Mortality

  All-cause mortality, Cardiovascular mortality (acute Myocardial Infarction, sudden death, heart failure, cerebrovascular, procedural), and Non-cardiovascular mortality

  Through study completion, an average of once a year, up to 20 years

• Heart Failure

  Congestive heart failure

  Through study completion, an average of once a year, up to 20 years

• Heart and/or Lung Transplantation

  Through study completion, an average of once a year, up to 20 years

• Left Ventricular and/or Right Ventricular Assist Device Implantation

  Through study completion, an average of once a year, up to 20 years

Secondary Outcomes (4)

• Cardiac Interventions

  Through study completion, an average of once a year, up to 20 years

• Arrhythmic

  Through study completion, an average of once a year

• Acute myocardial infarction

  Through study completion, an average of once a year, up to 20 years

• Acute Cerebrovascular Accident

  Through study completion, an average of once a year, up to 20 years

Study Arms (1)

Cardiovascular Magnetic Resonance

All patients who present to the Houston Methodist CMR Laboratory

Diagnostic Test: Cardiovascular Magnetic Resonance

Interventions

Cardiovascular Magnetic Resonance DIAGNOSTIC_TEST

Patients will undergo various CMR techniques designed to assess cardiovascular structure and function, tissue characteristics, and flow.

Cardiovascular Magnetic Resonance

Eligibility Criteria

• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients present to the Houston Methodist CMR Laboratory providing informed consent.

You may qualify if:

• All patients presenting to the Houston Methodist CMR Laboratory with known or suspected cardiovascular disease.

You may not qualify if:

• Unable to provide informed consent

Sponsors & Collaborators

• Dipan Shah: lead

Study Sites (1)

Houston Methodist Hospital

Houston, Texas, 77030, United States

RECRUITING

Related Publications (4)

• Malahfji M, Bhugra P, Nguyen DT, Crudo V, Saeed M, Reardon M, Nagueh SF, Zoghbi WA, Graviss EA, Shah DJ. Cardiac MRI Evaluation of Determinants and Prognostic Implications of Right Ventricular Dysfunction in Aortic Regurgitation. Radiol Cardiothorac Imaging. 2025 Feb;7(1):e230389. doi: 10.1148/ryct.230389.

  PMID: 39745324 DERIVED

• Tayal B, Faza NN, Nguyen DT, Malahfji M, Little S, Saeed M, Goel SS, Guha A, El-Tallawi KC, Graviss EA, Shah DJ. Association of secondary mitral regurgitation and right ventricular dysfunction among patients with non-ischaemic cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2024 Nov 27;25(12):1627-1635. doi: 10.1093/ehjci/jeae134.

  PMID: 38781428 DERIVED

• Tayal B, Debs D, Nabi F, Malahfji M, Little SH, Reardon M, Zoghbi W, Kleiman N, Shah DJ. Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure. JACC Cardiovasc Imaging. 2021 Apr;14(4):812-822. doi: 10.1016/j.jcmg.2020.11.004. Epub 2020 Dec 16.

  PMID: 33341417 DERIVED

• Kitkungvan D, Yang EY, El Tallawi KC, Nagueh SF, Nabi F, Khan MA, Nguyen DT, Graviss EA, Lawrie GM, Zoghbi WA, Bonow RO, Quinones MA, Shah DJ. Extracellular Volume in Primary Mitral Regurgitation. JACC Cardiovasc Imaging. 2021 Jun;14(6):1146-1160. doi: 10.1016/j.jcmg.2020.10.010. Epub 2020 Dec 16.

  PMID: 33341409 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Valve Diseases; Myocardial Ischemia; Cardiomyopathies

Condition Hierarchy (Ancestors)

Heart Diseases; Vascular Diseases

Study Officials

• Dipan Shah, MD

  The Methodist Hospital Research Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rachel Kronman-Gross, BS

CONTACT

7134416539; rkronman-gross@houstonmethodist.org

Mohamad Ghosn, PhD

CONTACT

7134419837; mghosn@houstonmethodist.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director of Cardiovascular Imaging

Study Record Dates

• First Submitted: January 24, 2020
• First Posted: February 24, 2020
• Study Start: April 1, 2008
• Primary Completion (Estimated): April 1, 2058
• Study Completion (Estimated): April 1, 2058
• Last Updated: April 20, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)