Blueberries and Exercise Inflammation

NCT05184855 | Completed

• 1 other identifier: 20-0213
• Study Type: interventional
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if 2-weeks supplementation with blueberries (1 cup/day) compared to placebo can mitigate muscle soreness and damage, and improve inflammation resolution and metabolic recovery during a 5-day period after engaging in an acute, 90-minute bout of eccentric exercise. The primary outcome will be plasma oxylipin levels, extending previously collected data showing that blueberry ingestion decreases post-exercise oxylipins generated from cytochrome P450 enzymes.

Conditions

Muscular Injury

Keywords

blueberries; exercise; inflammation; oxylipins; cytokines

Outcome Measures

Primary Outcomes (1)

• Plasma concentrations of pro-inflammatory oxylipins: 19-hydroxy-eicosatetraenoic acid (HETE), 20-HETE, 20-cooh-AA, 8,9-dihydroxy-eicosatrienoic (all ng/ml) acid; (diHETrE), 14,15-diHETrE

  Inflammation biomarkers

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after

Secondary Outcomes (2)

• Serum concentration of creatine kinase

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after

• Urine concentration of hippuric acid

  Change from pre-supplementation to post-2-weeks supplementation of blueberries or placebo

Study Arms (2)

Blueberry

EXPERIMENTAL

26 g freeze-dried blueberry powder per day or approximately one cup fresh blueberries equivalent; two weeks intake.

Dietary Supplement: Blueberry

Placebo

PLACEBO COMPARATOR

26 g placebo powder per day matched for color, taste, aroma; two weeks intake.

Dietary Supplement: Placebo

Interventions

Blueberry DIETARY_SUPPLEMENT

Blueberry powder intake

Blueberry

Placebo DIETARY_SUPPLEMENT

Placebo powder intake

Placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female, ages 18-50 years.
• Non-smoker.
• Body mass index less than 18.5-30 kg/m2 (not obese).
• Not engaged in regular resistance training (less than 3 sessions per week).
• Agree to train normally, maintain weight, and avoid the regular use of protein supplements, large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation and immune function (especially Advil, Motrin, aspirin, and similar anti-inflammatory drugs) for the duration of the study. (Participant will review supplement and medication use with the Research Manager during orientation).
• Agree to avoid consuming all berries including blueberries, raspberries, and strawberries.
• Agree to consume no more than an average of five servings per day of vegetables and fruit.
• Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
• Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.

You may not qualify if:

• Inability to comply with study requirements.
• Engaged in regular resistance training (3 or more sessions per week, on average).
• Body weight below 110 pounds.
• Pregnant or breastfeeding.
• Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
• Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
• History of allergic reactions to blueberry ingestion.
• Postmenopausal.

Sponsors & Collaborators

• Appalachian State University: lead

Study Sites (1)

Appalachian State University Human Performance Lab, North Carolina Research Campus

Kannapolis, North Carolina, 28081, United States

Location

MeSH Terms

Conditions

Motor Activity; Inflammation

Interventions

blueberry extract

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David C Nieman

  Appalachian State Univ

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Blueberry powder supplement and a carbohydrate- and fiber-matched placebo powder with flavoring, aroma, and coloring.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, parallel groups

Study Record Dates

• First Submitted: December 22, 2021
• First Posted: January 11, 2022
• Study Start: December 1, 2021
• Primary Completion: July 30, 2022
• Study Completion: August 15, 2022
• Last Updated: January 25, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)