Blueberries, Bananas, Exercise Recovery

NCT03445234 | Completed

• 1 other identifier: 17-0352
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The PURPOSE of this study is to investigate the combined influence of 2-weeks blueberry ingestion and banana ingestion (during exercise) on performance and in mitigating metabolic perturbation, immune dysfunction, and increase in inflammation following a 75-km cycling time trial. We hypothesize that the combination of 2-weeks ingestion of blueberries (versus placebo) and acute ingestion of bananas (versus water alone) during 75-km cycling will:

1. 1.Enhance performance.
2. 2.Attenuate the magnitude of metabolic perturbation due to exercise (using a targeted panel of metabolites) which may be associated with increased plasma levels of beneficial gut-derived phenolics.
3. 3.Attenuate post-exercise inflammation (as measured with cytokines, muscle damage markers, regulatory lipid mediators, ex-vivo monocyte cell cultures, and targeted immune proteins including S100A8 and S100A12).
4. 4.Counter post-exercise downturns in innate immune function (natural killer cell lytic activity), and viral defense (using an ex-vivo cell culture with Hela cells).

Conditions

Inflammatory Response; Metabolic Disturbance; Immune Suppression

Keywords

exercise; innate immune function; metabolomics; inflammation

Outcome Measures

Primary Outcomes (1)

• Inflammation

  Cytokines

  Change from pre-supplementation to post-2-weeks supplementation, and to six post-exercise time points (0, 1.5, 3.0, 5.0, 21, 45 hours)

Secondary Outcomes (6)

• Metabolite shifts

  Change from pre-supplementation to post-2-weeks supplementation, and to six post-exercise time points (0, 1.5, 3.0, 5.0, 21, 45 hours)

• Natural killer cell activity

  Change from pre-supplementation to post-2-weeks supplementation, and to six post-exercise time points (0, 1.5, 3.0, 5.0, 21, 45 hours)

• Exercise performance

  After the 2-week period of blueberry or placebo intake

• Targeted proteomics

  Change from pre-supplementation to post-2-weeks supplementation, and to six post-exercise time points (0, 1.5, 3.0, 5.0, 21, 45 hours)

• Muscle damage

  Change from pre-supplementation to post-2-weeks supplementation, and to six post-exercise time points (0, 1.5, 3.0, 5.0, 21, 45 hours)

Study Arms (4)

Blueberry

EXPERIMENTAL

Freeze-dried blueberry powder

Dietary Supplement: Blueberry

Placebo

PLACEBO COMPARATOR

Placebo powder

Dietary Supplement: Placebo

Banana

EXPERIMENTAL

Acute banana ingestion

Dietary Supplement: banana

No banana

EXPERIMENTAL

No banana ingestion

Dietary Supplement: No banana

Interventions

Blueberry DIETARY_SUPPLEMENT

26 g/day freeze-dried powder, 2 weeks duration

Also known as: Placebo

Blueberry

Placebo DIETARY_SUPPLEMENT

Placebo powder

Placebo

banana DIETARY_SUPPLEMENT

Acute ingestion of bananas 0.2 g carb/kg every 15 min exercise with water

Banana

No banana DIETARY_SUPPLEMENT

water only

No banana

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female.
• Ages 18-55 years.
• Non-smoker.
• Regularly compete in road races (category 1 to 5) and/or are capable of cycling 75 km in a laboratory setting (using own bicycles on CompuTrainer training systems).
• Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation and immune function (especially Advil, Motrin, aspirin, and similar anti-inflammatory drugs) for the duration of the 2.5-week study. If in doubt, please discuss your supplement and medication use with the Research Manager during orientation (Courtney Goodman).
• Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
• Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.

You may not qualify if:

• Inability to comply with study requirements.
• Body weight below 100 pounds.
• Pregnant or breastfeeding.
• Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
• Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
• History of allergic reactions to blueberries or bananas.

Sponsors & Collaborators

• Appalachian State University: lead
• Dole Food Company: collaborator

Study Sites (1)

North Carolina Research Campus, Human Performance Lab

Kannapolis, North Carolina, 28081, United States

Location

MeSH Terms

Conditions

Motor Activity; Inflammation

Interventions

blueberry extract

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David C. Nieman, DrPH

  Appalachian State Univ

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Blueberry freeze dried powder or placebo powder
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized parallel group

Study Record Dates

• First Submitted: August 10, 2017
• First Posted: February 26, 2018
• Study Start: September 11, 2017
• Primary Completion: December 15, 2017
• Study Completion: December 15, 2017
• Last Updated: February 26, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)