Pea Protein Supplementation and Muscle Damage

NCT03448328 | Completed

• 1 other identifier: 18-0165
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if supplementation with NUTRALYS pea protein isolate compared to whey protein and apple juice (carbohydrate, non-protein control) before, during, and after a 90-minute bout of eccentric exercise can attenuate exercise-induced muscle damage, inflammation, and delayed onset of muscle soreness (DOMS), and speed recovery of muscle function.

Conditions

Muscular Injury

Keywords

muscular strength; inflammation; protein

Outcome Measures

Primary Outcomes (1)

• Serum Creatine kinase

  Muscle damage marker

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

Secondary Outcomes (9)

• Serum Myoglobin

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

• Serum Lactate Dehydrogenase

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

• Delayed onset of muscle soreness

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

• Vertical jump

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

• Bench press

  Change from pre-exercise to post-exercise (immediately after, and 1-, 2-, 3-, and 4-days after)

Study Arms (3)

Pea Protein

EXPERIMENTAL

NUTRALYS pea protein supplement

Dietary Supplement: NUTRALYS pea protein supplement

Whey Protein

EXPERIMENTAL

Whey protein supplement

Dietary Supplement: Whey Protein

Apple juice

ACTIVE COMPARATOR

Apple juice

Dietary Supplement: Apple juice

Interventions

NUTRALYS pea protein supplement DIETARY_SUPPLEMENT

0.3 grams of protein per kilogram of body weight before and after eccentric exercise, and each of 4 mornings of recovery

Pea Protein

Whey Protein DIETARY_SUPPLEMENT

0.3 grams of protein per kilogram of body weight before and after eccentric exercise, and each of 4 mornings of recovery

Whey Protein

Apple juice DIETARY_SUPPLEMENT

1.2 calories per kilogram body weight before and after eccentric exercise, and each of 4 mornings of recovery

Apple juice

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male, female, 18 to 55 years of age.
• Non-athlete, and not engaged in regular resistance training (less than 3 sessions per week).
• BMI under 30 (non-obese).
• At "low risk" status for cardiovascular disease (as determined with a screening questionnaire).
• Agree to avoid the use of protein and large-dose vitamin/mineral supplements (above 100% of recommended dietary allowances), herbs, and all medications (in particular, NSAIDs such as ibuprofen and aspirin) during the week of the project.

You may not qualify if:

• Inability to comply with study requirements.
• Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
• Current, active history of coronary heart disease, stroke, cancer, diabetes, rheumatoid arthritis, high blood pressure, kidney disease, liver disease, blood disease, hormonal disease, or metabolic disease.
• History of cancer in the 5 years prior to the screening visit (except skin or cervical cancer that was successfully treated).
• Current use of any type of medication (or unwillingness to stop use of over-the-counter medications two weeks before the start of the study).
• Recent history of musculoskeletal trauma (fracture, strain, sprain, etc.) that has not fully healed prior to baseline testing.
• Females: pregnant or breastfeeding; or body weight under 100 pounds.

Sponsors & Collaborators

• Appalachian State University: lead
• Roquette Freres: collaborator

Study Sites (1)

Appalachian State University Human Performance Lab, North Carolina Research Campus

Kannapolis, North Carolina, 28081, United States

Location

MeSH Terms

Conditions

Inflammation

Interventions

Whey Proteins

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• David C Nieman, DrPH

  Appalachian State Univ

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, parallel group

Study Record Dates

• First Submitted: February 22, 2018
• First Posted: February 28, 2018
• Study Start: March 5, 2018
• Primary Completion: February 15, 2020
• Study Completion: June 1, 2020
• Last Updated: July 15, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)