NCT05144711|Unknown
Management of Deep Carious Lesions in Adults
Selective Versus Nonselective Caries Excavation in Adults: Randomized Clinical Trial
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Selective Versus Nonselective Caries Excavation in Adults: Randomized Clinical Trial
Sponsor study identifier
interventional
200
1 country
1
Study Start
October 3, 2021
Actual (reported)Primary Completion
October 20, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Dental caries is one of the most prevalent non-communicable disease. However, despite its prevalence there is no consensus on how much caries to remove prior to placing a restoration to achieve optimal outcomes. Evidence for selective compared to complete nonselective excavation suggests there may be benefit for selective removal in sustaining tooth vitality while histological studies reveal that the remaining dentine is actually infected and may cause loss of vitality in long term. The aim of this study is to randomly compare selective to non-elective excavation methods in carious mature permanent teeth with symptoms of reversible pulpitis
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 3, 2021
Actual (reported)November 22, 2021
Actual (reported)December 3, 2021
Actual (reported)October 20, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
June 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Absence of clinical symptoms
Relief of pain after the procedure
48 hours
Pulp vitality
6, 12, 24, 48 months
Cries will be removed from the peripheries of the cavity, while only soft caries will be removed from the plural side leaving stained leathery dentine that can not be removed by hand instruments. Biodentine will be placed and the cavity will be restored.
Caries will be cleaned form all cavity peripheries and floor. Biodentine will be placed and the toothy will be restored.
Selective caries excavation leaving stained but leathery dentine towards the pulp
Complete excavation of caries regardless of the risk of pulp exposure
Jordan University of science and technology
Irbid, 21110, Jordan
Taha NA, About I, Sedgley CM, Messer HH. Conservative Management of Mature Permanent Teeth with Carious Pulp Exposure. J Endod. 2020 Sep;46(9S):S33-S41. doi: 10.1016/j.joen.2020.06.025.
Taha NA, Ali MM, Abidin IZ, Khader YS. Pulp survival and postoperative treatment needs following selective vs. total caries removal in mature permanent teeth with reversible pulpitis: A randomized clinical trial. J Dent. 2024 Dec;151:105408. doi: 10.1016/j.jdent.2024.105408. Epub 2024 Oct 22.
Nessrin Taha, PhD
Jordan University of Science and Technology
First Submitted
November 22, 2021
First Posted
December 3, 2021
Study Start
October 3, 2021
Actual (reported)Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure
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Primary Completion
October 20, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
September 13, 2022
Record last verified: 2022-09
When recruitment is completed and the data is analyzed and submitted for publication. Data may be provided for the benefit of other researchers.
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Source: ClinicalTrials.gov.
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