NCT04375215

Brief Summary

The aim of this clinical study is to compare and evaluate the Success of Selective Caries vs Stepwise Caries Removal Techniques in treatment of dental caries.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
146

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2020

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2020

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 24, 2020

Completed
11 days until next milestone

First Posted

Study publicly available on registry

May 5, 2020

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2021

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 15, 2021

Completed
Last Updated

May 5, 2020

Status Verified

May 1, 2020

Enrollment Period

1.3 years

First QC Date

April 24, 2020

Last Update Submit

May 3, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Clinical success

    Clinical success will be judged by following criteria * Positive response on vitality test. * Absence of pain on percussion and any other signs and/or symptoms of irreversible pulpitis and pulp necrosis Criteria for failure will be * Negative response on pulp vitality test. * Tenderness to percussion and teeth exhibiting any clinical signs and/or symptoms of irreversible pulpitis and pulp necrosis.

    Baseline to 12 months

Secondary Outcomes (1)

  • Radiographic Success

    Baseline to 12 months

Study Arms (2)

Selective caries removal to soft dentin (one step)

ACTIVE COMPARATOR

In selective caries removal to soft dentine, after caries excavation application of liner will be done on pulpal floor. Teeth will then be filled with composite resin material.

Procedure: Selective caries removal

Stepwise caries removal (two step)

ACTIVE COMPARATOR

The stepwise caries removal is a two step procedure. The first step is similar to selective caries removal to soft dentin group. In the second step, after 6 months lesion will be re-entered to remove remaining carious tissue till firm dentin is encountered. Once all the caries is removed from floor of cavity a liner followed by final restoration with composite will be performed.

Procedure: Stepwise caries removal

Interventions

After caries removal restoration of tooth will be performed

Selective caries removal to soft dentin (one step)

After caries removal restoration of tooth will be performed

Stepwise caries removal (two step)

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Outpatient in age range of 18yr-60yr
  • Permanent mandibular posterior teeth with deep caries
  • Caries extending to \>3/4 of dentin with a layer of sound dentin between pulp and carious tissue as seen on radiograph
  • Positive response to cold test and electric pulp test

You may not qualify if:

  • Any general disease affecting the caries e.g. patient under head and neck radiotherapy
  • Patients with immuno-compromised status
  • Tooth with fracture line, cracks.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Post Graduate Institute of Dental Science

Rohtak, Haryana, 124001, India

RECRUITING

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Prospective randomized clinical study
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 24, 2020

First Posted

May 5, 2020

Study Start

January 1, 2020

Primary Completion

April 30, 2021

Study Completion

June 15, 2021

Last Updated

May 5, 2020

Record last verified: 2020-05

Data Sharing

IPD Sharing
Will not share

Locations