NCT05133726

Brief Summary

Avoidable hospital readmissions are a pressing problem for our healthcare system. They lead to substantial human suffering and higher financial costs. Most discharged psychiatric inpatients in Alberta are offered follow-up appointments with Alberta Health Services (AHS) Addiction and Mental Health (AMH) community providers. Patients often wait 28-38 weeks for their first appointment, which leads many to miss their first appointments, and increases the likelihood of relapse. As a result, patients discharged into the community are readmitted to the Emergency Department (ED). To address this significant revolving door, the investigators will implement a low-cost, evidence-based system that delivers daily supportive texts to patients' mobile phones. The text messages developed by experts and service users, based on cognitive behavioral therapy principles. Our proposed program also includes peer support from previous mental health patients who have had similar challenges as participants, but are now in recovery. In this way, the investigators aim to reduce the psychological treatment and support gap for AMH patients who have been discharged from acute care and are scheduled to receive mental health and psychiatric treatment from A\&MH services after a long wait. Our pilot test of these interventions provide evidence that psychiatric readmissions, and emergency department visits can be reduced by 10-25% if implemented at scale in Alberta, thus resulting in cost-savings for individuals and the province.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,132

participants targeted

Target at P75+ for not_applicable

Timeline
2mo left

Started Mar 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

7 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress97%
Mar 2022Jun 2026

First Submitted

Initial submission to the registry

October 21, 2021

Completed
1 month until next milestone

First Posted

Study publicly available on registry

November 24, 2021

Completed
3 months until next milestone

Study Start

First participant enrolled

March 1, 2022

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2024

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Expected
Last Updated

August 21, 2025

Status Verified

August 1, 2025

Enrollment Period

2.1 years

First QC Date

October 21, 2021

Last Update Submit

August 20, 2025

Conditions

Keywords

Psychiatric IllnessPeer supportText MessageElectronic health (eHealth)Readmission rate

Outcome Measures

Primary Outcomes (1)

  • Change in 30 day readmission rate

    Readmission to acute psychiatric care within 30 days of discharge

    baseline, 24 weeks, 52 weeks

Secondary Outcomes (5)

  • Change in Clinical Outcomes in Routine Evaluation 10 (CORE-10) scores

    baseline, 24 weeks, 52 weeks

  • Change in EuroQol- 5 Dimension (EQ-5D)scores

    baseline, 24 weeks, 52 weeks

  • Change in Patient Health Questionnaire (PHQ-9) scores

    baseline, 24 weeks, 52 weeks

  • Change in Recovery Assessment Scale (RAS)scores

    baseline, 24 weeks, 52 weeks

  • Change in Brief Resilience Scale scores

    baseline, 24 weeks, 52 weeks

Other Outcomes (4)

  • Change in the Reach of the Text4Support

    baseline, 24 weeks, 52 weeks

  • Change in the fidelity of the intervention

    baseline, 24 weeks, 52 weeks

  • Sustainability of the intervention

    52 weeks

  • +1 more other outcomes

Study Arms (3)

Text Message cluster

EXPERIMENTAL

This arm will receive only daily text message support for six months plus weekly text message over 6 weeks (six information text messages all together)

Other: Text4Support

Text message with or without peer support

EXPERIMENTAL

All individuals in this cluster will receive daily text message support for six months plus weekly text message over 6 weeks (six information text messages all together) with some selected members also receiving peer support for six months

Other: Text4SupportOther: Peer support

Control group

NO INTERVENTION

This group will only receive usual care plus weekly text message over 6 weeks (six information text messages all together) with provides information about community services

Interventions

Daily supportive text messages

Also known as: Supportive messages
Text Message clusterText message with or without peer support

Meeting with peers who have lived experiences with similar diagnoses but are in recovery

Text message with or without peer support

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients who are 18 or 65 years of age
  • Able to provide informed written consent have been diagnosed with mental health condition, and are ready for discharge.
  • Patients should have a mobile device capable of receiving text messages

You may not qualify if:

  • If they have an addiction disorder but not a mental health diagnosis
  • Are not capable of reading text messages from a mobile device or if they know they will be out of town during the 12-month follow-up period.
  • Patients are also ineligible if they do not consent to take part in the study,

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (7)

Royal Alexander Hospital

Edmonton, Alberta, T5H2V1, Canada

Location

Alberta Hospital

Edmonton, Alberta, T5J2J7, Canada

Location

Misericordia Community Hospital

Edmonton, Alberta, T5R4H5, Canada

Location

University of Alberta Hospital

Edmonton, Alberta, T6G2R3, Canada

Location

Grey Nuns Hospital

Edmonton, Alberta, T6L5X8, Canada

Location

Northern Lights Regional Health Centre

Fort McMurray, Alberta, Canada

Location

Foothills Hospital

Calgary, Canada

Location

Related Publications (9)

  • Adu MK, Shalaby R, Eboreime E, Sapara A, Nkire N, Chawla R, Chima C, Achor M, Osiogo F, Chue P, Greenshaw AJ, Agyapong VI. Text Messaging Versus Email Messaging to Support Patients With Major Depressive Disorder: Protocol for a Randomized Hybrid Type II Effectiveness-Implementation Trial. JMIR Res Protoc. 2021 Oct 13;10(10):e29495. doi: 10.2196/29495.

    PMID: 34643541BACKGROUND
  • Agyapong VIO, Juhas M, Ohinmaa A, Omeje J, Mrklas K, Suen VYM, Dursun SM, Greenshaw AJ. Randomized controlled pilot trial of supportive text messages for patients with depression. BMC Psychiatry. 2017 Aug 2;17(1):286. doi: 10.1186/s12888-017-1448-2.

    PMID: 28768493BACKGROUND
  • Shalaby RAH, Agyapong VIO. Peer Support in Mental Health: Literature Review. JMIR Ment Health. 2020 Jun 9;7(6):e15572. doi: 10.2196/15572.

    PMID: 32357127BACKGROUND
  • Agyapong VI, Mrklas K, Juhas M, Omeje J, Ohinmaa A, Dursun SM, Greenshaw AJ. Cross-sectional survey evaluating Text4Mood: mobile health program to reduce psychological treatment gap in mental healthcare in Alberta through daily supportive text messages. BMC Psychiatry. 2016 Nov 8;16(1):378. doi: 10.1186/s12888-016-1104-2.

    PMID: 27821096BACKGROUND
  • Agyapong VI, Ahern S, McLoughlin DM, Farren CK. Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial. J Affect Disord. 2012 Dec 10;141(2-3):168-76. doi: 10.1016/j.jad.2012.02.040. Epub 2012 Mar 29.

    PMID: 22464008BACKGROUND
  • Mao W, Shalaby R, Owusu E, Elgendy HE, Agyapong B, Chue P, Silverstone PH, Greenshaw AJ, Li XM, Eboreime E, Vuong W, Ohinmaa A, MacMaster FP, Agyapong V. Predictors of Psychiatric Emergency Department Visits Following Inpatient Discharge: Secondary Analysis of a Stepped-Wedge Cluster Randomized Trial. JMIR Form Res. 2025 Oct 30. doi: 10.2196/79184. Online ahead of print.

  • Agyapong VIO, Shalaby R, Agyapong B, Mao W, Owusu E, Elgendy HE, Eboreime E, Silverstone PH, Chue P, Li XM, Vuong W, Ohinmaa A, MacMaster F, Greenshaw AJ. Effectiveness of Text Messages and Text Messages Plus Peer Support on Psychiatric Readmission and Length of Stay: Outcomes From a Quantitative Stepped-Wedge Cluster Randomized Trial. JMIR Ment Health. 2025 Nov 18;12:e81760. doi: 10.2196/81760.

  • Owusu E, Mao W, Shalaby R, Elgendy HE, Agyapong B, Eboreime E, Lawal MA, Nkire N, Wei Y, Silverstone PH, Chue P, Li XM, Vuong W, Ohinmaa A, Taylor V, Hilario CT, Greenshaw AJ, Agyapong VIO. The prevalence and correlates of low resilience in patients prior to discharge from acute psychiatric units in Alberta, Canada. BMC Psychiatry. 2025 Mar 27;25(1):295. doi: 10.1186/s12888-025-06704-8.

  • Eboreime E, Shalaby R, Mao W, Owusu E, Vuong W, Surood S, Bales K, MacMaster FP, McNeil D, Rittenbach K, Ohinmaa A, Bremault-Phillips S, Hilario C, Greiner R, Knox M, Chafe J, Coulombe J, Xin-Min L, McLean C, Rathwell R, Snaterse M, Spurvey P, Taylor VH, McLean S, Urichuk L, Tzeggai B, McCabe C, Grauwiler D, Jordan S, Brown E, Fors L, Savard T, Grunau M, Kelton F, Stauffer S, Cao B, Chue P, Abba-Aji A, Silverstone P, Nwachukwu I, Greenshaw A, Agyapong VIO. Reducing readmission rates for individuals discharged from acute psychiatric care in Alberta using peer and text message support: Protocol for an innovative supportive program. BMC Health Serv Res. 2022 Mar 12;22(1):332. doi: 10.1186/s12913-022-07510-8.

Related Links

MeSH Terms

Conditions

Mental Disorders

Study Officials

  • Vincent Agyapong, MD,PhD

    University of Alberta

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SEQUENTIAL
Model Details: Stepped edge design
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 21, 2021

First Posted

November 24, 2021

Study Start

March 1, 2022

Primary Completion

March 31, 2024

Study Completion (Estimated)

June 30, 2026

Last Updated

August 21, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Health service utilization information will be collected (for the year prior to admission, and the year post-discharge). This data will include: inpatient admissions and length of stay, readmissions, completed appointments, Emergency Department presentations, Emergency Medical Services use, community services appointments, crisis and urgent service calls, appointment no show rates

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Data will be available from the onset of collection till 5 years after the study
Access Criteria
All the hard and electronic copies and other research project related documents will be stored in secure, locked locations and only staff working on this research project will have access to it. Electronic versions of the data will be securely stored in AHS offices. The data master list containing identifying data, will be stored separately from other study data, and will only be accessible to the principal investigator and/or their delegate(s)

Locations